{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:08Z","timestamp":1791495128594,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      Mengding yellow bud polyphenols (MYBPs), as a plant active ingredient that may protect the liver, have not yet been elucidated for the potential molecular mechanism in preventing carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      ) induced acute liver injury (ALI) in mice. The MYBPs monomers compounds were explored by the high\u2010performance liquid chromatography (HPLC). Mice were administered silymarin (100\u00a0mg\/kg b.w.) or MYBPs (50 and 100\u00a0mg\/kg b.w.) 2 weeks prior to CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010induced ALI. The liver function indexes, histopathological observation, biochemical indexes, and mRNA and protein expressions were determine. The MYBPs effectively reduced the mice liver weights, liver indexes, liver pathological injury, and the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), and total cholesterol (TC). Similarly, the MYBPs decreased the interleukin (IL)\u20106, IL\u201012, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and interferon (IFN)\u2010\u03b3 serum levels, reduced the liver tissues myeloperoxidase (MPO) and malondialdehyde (MDA) levels, and elevated the superoxide dismutase (SOD) and glutathione (GSH) levels. The cuprozinc\u2010superoxide dismutase (Cu\/Zn\u2010SOD), manganese\u2010superoxide dismutase (Mn\u2010SOD), catalase (CAT), and B\u2010cells inhibitor\u2010\u03b1 (I\u03baB\u2010\u03b1) expressions markedly increased. Additionally, the MYBPs significantly decreased the nuclear factor (NF)\u2010\u03baB, TNF\u2010\u03b1, IL\u20101 beta, inducible NOS (iNOS), and cyclooxygenase (COX)\u20102 expressions. HPLC showed that MYBPs contained gallic acid (GA), (\u2212)\u2010epigallocatechin (EGC), epigallocatechin gallate (EGCG), and (\u2212)\u2010epicatechin gallate (ECG). Briefly, MYBPs effectively prevented mice CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010induced ALI by inhibiting oxidative stress and inflammatory pathways, and its preventive effect was dose\u2010dependent with its concentration. This study provided a scientific basis for the development of MYBPs into functional food as well as a new idea for clinical prevention and treatment of human ALI.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Practical Application<\/jats:bold>\n                      : MYBPs can alleviate CCl\n                      <jats:sub>4<\/jats:sub>\n                      \u2010induced Hepatotoxicity by raising the antioxidant and antiinflammatory status and upregulating the antioxidant and antiinflammatory\u2010related genes and protein.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70254","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:21:57Z","timestamp":1746606117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mengding Yellow Bud Polyphenols Protect Against CCl\n                    <sub>4<\/sub>\n                    \u2010induced Hepatotoxicity in Mice Via Inhibiting Oxidative Stress and Inflammation"],"prefix":"10.1111","volume":"90","author":[{"given":"Ranran","family":"Wang","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Child Nutrition and Health Development, Chongqing Engineering Research Center of Functional Food, Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education  Chongqing P.R. 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