{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:29:41Z","timestamp":1762172981671,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      Pipefish, a traditional tonic in Chinese food, has attracted attention from both scientific and industrial interest for its potential protective effects on the prostate. The research investigates the structural characteristics and anti\u2010prostatic hyperplasia properties of petroleum ether extract (PE) from\n                      <jats:italic>Syngnathus schlegeli<\/jats:italic>\n                      . PE contained 1776 distinct lipid compounds, with phospholipids accounting for as much as 63.41% of the total. Among these phospholipids, the relative contents of lysolipid phosphatidylcholine and phosphatidylserine (PS) are relatively high, at 40.73% and 6.02%, respectively. PE upregulated the expression levels of Bax, p21WAF1\/Cip1, and p53 proteins while downregulating Cyclin D1 and CDK2 proteins in TP\u2010induced RWPE\u20101 cells. This modulation resulted in cell cycle arrest and a subsequent inhibition of cell proliferation. Transcriptome analysis revealed that PE inhibited integrin ITGB3, thereby disrupting ECM\u2010receptor interaction. This disruption affects cytoskeletal remodeling and focal adhesion, while also inhibiting the downstream PI3K\u2010Akt signaling pathway. Consequently, these effects impede the progression of TP\u2010induced benign prostatic hyperplasia (BPH). Notably, saturated PS exhibited a strong affinity for ITGB3 and could form stable complexes. These results indicate that PS compounds in PE have potential antiproliferative effects on BPH and could serve as a promising active compound.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Practical Application<\/jats:bold>\n                      : The pipefish extract PE obtained in this study demonstrates significant inhibitory effects on BPH while exhibiting low toxicity. This suggests a promising potential for its development as a functional food aimed at enhancing male reproductive health, addressing the healthcare needs of a significant portion of middle\u2010aged and elderly men.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70283","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:55:12Z","timestamp":1750809312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and Antiproliferative Effect of\n                    <i>Syngnathus schlegeli<\/i>\n                    Extracts on Benign Prostatic Hyperplastic Cells"],"prefix":"10.1111","volume":"90","author":[{"given":"Bingna","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology Chinese Academy 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