{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:35:36Z","timestamp":1778124936660,"version":"3.51.4"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>Non\u2010alcoholic steatohepatitis (NASH) is a globally recognized liver disease. Anti\u2010oxidative vitamins, such as vitamin C (VC) and vitamin E (VE), are used to treat NASH in humans. In addition, some carotenoids (e.g., astaxanthin, \u03b2\u2010cryptoxanthin, fucoxanthin, lycopene, and zeaxanthin) could suppress the progression of NASH in a mouse model. However, it is unclear whether \u03b2\u2010carotene is effective against NASH. Therefore, we examined the effects of \u03b2\u2010carotene on diet\u2010induced NASH in mice. C57BL\/6J male mice (10 weeks of age) were fed a control diet or NASH diet containing various amounts of \u03b2\u2010carotene (0.0005%\u20130.5% [w\/w]). A 12\u2010week feeding NASH diet induced NASH in a mouse model. This model presented increased liver weight, plasma levels of hepatic marker enzymes (aspartate transaminase; AST, alanine transaminase; ALT), hepatic triglycerides (TG) content, and NAFLD activity score. The physiological dose (0.0005%\u20130.005%) of \u03b2\u2010carotene failed to suppress the progression of NASH. However, high\u2010dose (0.5%) of \u03b2\u2010carotene suppressed hepatic lipid accumulation and NASH progression, especially lobular inflammation, in the NAFLD activity score. In conclusion, a high\u2010dose of \u03b2\u2010carotene intake prevented hepatic lipid accumulation and the progression of NASH in a mouse model. In contrast, the physiological dose of \u03b2\u2010carotene did not show any beneficial effects on NASH. However, \u03b2\u2010carotene's presence in food is valuable and could be expanded to reflect real\u2010world implications. Further studies, especially observational studies, are needed to clarify whether \u03b2\u2010carotene can prevent the progression of NASH in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Practical Application<\/jats:bold>\n                      : The physiological dose of \u03b2\u2010carotene did not show any beneficial effects on NASH. However, a high\u2010dose of \u03b2\u2010carotene suppressed the progression of NASH, especially steatosis and lobular inflammation, in a mouse model. Further studies are needed to clarify whether \u03b2\u2010carotene can prevent the progression of NASH in humans. \u03b2\u2010Carotene is known to have various biological functions in addition to its role as provitamin A. So, active consumption of \u03b2\u2010carotene via regular foods, but not dietary supplements, is recommended, even if the effect on NASH in humans is unclear.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70363","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:09:14Z","timestamp":1750810154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010Dose \u03b2\u2010Carotene Suppresses Non\u2010Alcoholic Steatohepatitis Progression in a Mouse Model"],"prefix":"10.1111","volume":"90","author":[{"given":"Sachina","family":"Suzuki","sequence":"first","affiliation":[{"name":"Faculty of Healthcare Tokyo Healthcare University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Umegaki","sequence":"additional","affiliation":[{"name":"Faculty of Food Health Science Showa Women's University  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