{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T12:22:26Z","timestamp":1769257346818,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      The growing interest in plant\u2010based bioactives has intensified research into their therapeutic potential. This study investigated the chemical profile, antioxidant properties, and enzyme inhibitory effects of methanol extracts from\n                      <jats:italic>Campanula lyrata<\/jats:italic>\n                      subsp.\n                      <jats:italic>lyrata<\/jats:italic>\n                      , obtained via maceration (MAC\u2010ME), Soxhlet (SOE\u2010ME), and ultrasound\u2010assisted extraction (UAE\u2010ME). Among the extracts, MAC\u2010ME contained the highest total phenolic (41.76\u00a0mg GAE\/g) and flavonoid (23.68\u00a0mg RE\/g) contents. In antioxidant assays, SOE\u2010ME exhibited the strongest DPPH radical scavenging activity (IC\n                      <jats:sub>50<\/jats:sub>\n                      : 1.17\u00a0mg\/mL), while all extracts displayed comparable reducing power in CUPRAC and FRAP assays (EC\n                      <jats:sub>50<\/jats:sub>\n                      : 0.50\u20130.77\u00a0mg\/mL), indicating moderate antioxidant potential. Enzyme inhibition results revealed that SOE\u2010ME showed the most potent AChE (IC\n                      <jats:sub>50<\/jats:sub>\n                      : 1.18 \u00b1 0.03\u00a0mg\/mL) and tyrosinase (IC\n                      <jats:sub>50<\/jats:sub>\n                      : 1.45 \u00b1 0.01\u00a0mg\/mL) inhibition, whereas MAC\u2010ME demonstrated the highest \u03b1\u2010amylase inhibition (IC\n                      <jats:sub>50<\/jats:sub>\n                      : 2.11 \u00b1 0.01\u00a0mg\/mL). These findings suggest selective bioactivity profiles depending on the extraction technique. Molecular docking supported the in vitro results, showing strong binding affinities of chlorogenic acid (\u0394\n                      <jats:italic>G<\/jats:italic>\n                      = \u22129.25\u00a0kcal\/mol for AChE) and hesperidin (\u0394\n                      <jats:italic>G<\/jats:italic>\n                      = \u22129.05\u00a0kcal\/mol for \u03b1\u2010amylase), with simultaneous docking indicating potential synergistic interactions (\u0394\n                      <jats:italic>G<\/jats:italic>\n                      up to \u221212.65\u00a0kcal\/mol). Overall, the extracts\u2014especially SOE\u2010ME\u2014demonstrated promising multi\u2010target bioactivity, underscoring the pharmacological potential of\n                      <jats:italic>C. lyrata<\/jats:italic>\n                      subsp.\n                      <jats:italic>lyrata<\/jats:italic>\n                      in managing oxidative stress and enzyme\u2010related disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70368","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:24:37Z","timestamp":1754465077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeted Phenolic Profiling, Antioxidant Activities, and Enzyme Inhibition Potential of\n                    <i>Campanula lyrata<\/i>\n                    subsp.\n                    <i>lyrata<\/i>\n                    Extracts With Molecular Docking Insights"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-3371","authenticated-orcid":false,"given":"Fatma Ozlem","family":"Kargin Solmaz","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-0681","authenticated-orcid":false,"given":"Bulent","family":"Kirkan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-0703","authenticated-orcid":false,"given":"Erman Salih","family":"Istifli","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Literature Cukurova University  Adana T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-2520","authenticated-orcid":false,"given":"Cengiz","family":"Sarikurkcu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-5188","authenticated-orcid":false,"given":"Bektas","family":"Tepe","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Kilis 7 Aralik University  Kilis T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"1","article-title":"\u03b1\u2010glucosidase Inhibition Activity and Antioxidant Properties of Aerial Parts Methanol Extract From Silene ampullata Bioss and Campanula involucrate Auch. 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