{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:06:30Z","timestamp":1792670790471,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"Department of Science and Technology of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Hemerocallis citrina<\/jats:italic>\n                    Baroni is a healthy vegetable, and consumption of fresh\n                    <jats:italic>H. citrina<\/jats:italic>\n                    can lead to defecation. However, the laxative ingredients are still not known. In the present study, the laxative effect of fresh\n                    <jats:italic>H. citrina<\/jats:italic>\n                    extracts was primarily evaluated by loperamide\u2010induced constipated mice, and the aqueous extracts (1500 and 3000\u00a0mg\/kg) showed a significant laxative effect. The aqueous extracts were divided into three parts (0%, 30%, and 50% HCW) by macroreticular resin, and all of them were further evaluated. Based on comprehensive analysis of multiple indices, the constipation\u2010relieving effect of 30% HCW was found to be superior to that of 0% and 50% HCW. A total of 16 compounds were identified from 30% HCW by the ultra\u2010performance liquid chromatography\u2010quadrupole\u2010time of flight\u2010mass spectrometry (UPLC\u2010Q\u2010TOF\u2010MS) method. Three high\u2010level ingredients including chlorogenic acid (3), 4\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010p\u2010coumaroylquinic acid (6) and rutin (13) were selected to further evaluate their laxative effect. The experimental results demonstrate that 4\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010p\u2010coumaroylquinic acid increases defecation frequency in constipated mice, enhances fecal moisture content, and promotes small intestinal motility in constipated mice. The high\u2010dose 4\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010p\u2010coumaroylquinic acid treatment group exhibited higher mean small intestinal transit rates compared to the high\u2010dose chlorogenic acid and rutin groups. Additionally, this compound effectively alleviated loperamide\u2010induced pathological damage, including thinning of the muscle layer and reduced goblet cell numbers, thereby enhancing small intestinal motility, increasing fecal moisture content, and facilitating defecation. This is the first study to identify 4\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010p\u2010coumaroylquinic acid as a key laxative component in fresh\n                    <jats:italic>H. citrina<\/jats:italic>\n                    Baroni, providing novel insights into its application in functional food or pharmaceutical development.\n                  <\/jats:p>","DOI":"10.1111\/1750-3841.70483","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:50:28Z","timestamp":1754916628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laxative Ingredients of Fresh\n                    <i>Hemerocallis citrina<\/i>\n                    Baroni"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3003-9560","authenticated-orcid":false,"given":"Yuan","family":"Hu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FaYing","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Food Science and Technology Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishuo","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewei","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Qing","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Hunan Agricultural University  Changsha China"},{"name":"Changsha Changxu Biotechnology Ltd.  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