{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:45:47Z","timestamp":1787244347460,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977020"],"award-info":[{"award-number":["21977020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The precise molecular mechanisms through which gut microbiota mediate the antihypertensive effects of probiotic fermented milk (PFM) remain largely unexplored. This study aimed to elucidate these mechanisms by employing a multi\u2010omics approach, combined with metagenomic deep sequencing technology, non\u2010targeted metabolomics technology, and antibody chip protein detection technology to elucidate the potential mechanisms behind the antihypertensive effects of milk fermented by\n                      <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                      SR37\u20103 (PFM\u2010SR37\u20103) in spontaneously hypertensive rats (SHR). Our findings demonstrate that PFM\u2010SR37\u20103 intervention significantly reduces blood pressure in SHR and is associated with partial inactivation of the renin\u2010angiotensin system (RAS). Notably, long\u2010term administration of PFM\u2010SR37\u20103 inhibited the progressive rise in systolic blood pressure (SBP), with final measurements of 187.17 \u00b1 3.61\u00a0mmHg in the model group versus 172.21 \u00b1 11.81\u00a0mmHg in the PFM\u2010SR37\u20103\u2010treated group after 4 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). PFM\u2010SR37\u20103 modulates key host metabolic pathways (especially arachidonic acid metabolism) by reshaping the gut microbiota (such as enrichment of\n                      <jats:italic>Lactobacillaceae<\/jats:italic>\n                      ), with concomitant reductions in the levels of proinflammatory cytokines (such as ICAM\u20101 and Fractalkine). This \u201cgut\u2010immune\u201d pathway is an important complement to its partial inhibition of the RAS. Collectively, these data highlight strong associations between PFM\u2010induced gut microbial shifts and antihypertensive effects, providing a multi\u2010faceted view of the potential mechanisms and underscoring the therapeutic potential of PFM in managing hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70654","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T06:09:06Z","timestamp":1762582146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gut Microbiota\u2010Mediated Antihypertensive Effects of Probiotic Fermented Milk: A Multi\u2010Omics Study"],"prefix":"10.1111","volume":"90","author":[{"given":"Lin","family":"Yuan","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of 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