{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:46:39Z","timestamp":1791243999560,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Ulcerative colitis (UC), a precursor of colorectal cancer (CRC) driven by Wnt\/\u03b2\u2010Catenin pathway activation, may be mitigated by hulless barley grass (HBG), a high\u2010altitude crop with antioxidant, anti\u2010inflammatory, and anti\u2010tumor effects. A previous study found that HBG had palliative effects on UC. The effects and mechanism of HBG phenolic (PE), polysaccharide (PSE), and lipid extracts (LE) on UC associated CRC were investigated by establishing an azoxymethane (AOM)\/dextran sodium sulfate (DSS)\u2010induced CRC mice model. Compared to CRC mice, the PE group (600 mg\/kg\/d) exhibited a 41.4% decrease in tumor numbers and a 16.5% decrease in the proportion of tumors more than 2 mm in size. In addition, PE effectively alleviated the expression of pro\u2010inflammatory cytokines, including tumor necrosis factor\u2010\u03b1 (\n                      <jats:italic>Tnf\u03b1<\/jats:italic>\n                      ), interleukin\u20106 (\n                      <jats:italic>Il6<\/jats:italic>\n                      ), and\n                      <jats:italic>Il1\u03b2<\/jats:italic>\n                      , and genes associated with tumorigenesis (prostaglandin\u2010endoperoxide synthase 2 (\n                      <jats:italic>Ptgs2<\/jats:italic>\n                      ), epidermal growth factor receptor (\n                      <jats:italic>Egfr<\/jats:italic>\n                      ), and nitric oxide synthase 2 (\n                      <jats:italic>Nos2<\/jats:italic>\n                      ), and increased the diversity and abundance of intestinal flora. Quercetin\u20103\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010(2\u2033,6\u2033\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010L\u2010dirhamnopyranosyl)\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010D\u2010galactopyranoside, Quercetin\u20103\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010D\u2010rutinoside, and Baicalin\u20107\u2010diglucoside were identified as the main components of PE. Furthermore, PE downregulated \u03b2\u2010Catenin (\n                      <jats:italic>Ctnnb1<\/jats:italic>\n                      ) from 4.81 to 1.46 fold change,\n                      <jats:italic>Myc<\/jats:italic>\n                      from 4.27 to 1.62 (fold), and Cyclin D1 (\n                      <jats:italic>Ccnd1<\/jats:italic>\n                      ) from 5.43 to 2.35 fold. Both PSE (400 mg\/kg\/d) and LE (200 mg\/kg\/d) significantly decreased\n                      <jats:italic>Tnf\u03b1<\/jats:italic>\n                      and\n                      <jats:italic>Il6<\/jats:italic>\n                      mRNA expression, and no significant difference in\n                      <jats:italic>Ptgs2<\/jats:italic>\n                      and\n                      <jats:italic>Egfr<\/jats:italic>\n                      was observed between the PSE and LE groups and the model group. These findings indicated that PE had the potential to treat CRC, providing a preventive strategy for UC associated CRC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>This research indicates that phenolic extracts from hulless barley grass have potential for development as natural dietary supplements or functional food ingredients aimed at preventing colitis\u2010associated colorectal cancer. By significantly reducing pro\u2010inflammatory cytokines and suppressing aberrant initiation of the Wnt\/\u03b2\u2010catenin signaling pathway, these extracts may alleviate chronic intestinal inflammation. In addition, they contribute to the maintenance of a healthier gut microbiota, thereby supporting intestinal barrier function. Together, these findings highlight a promising natural strategy to improve gut health and lower the risk of inflammation\u2010related colorectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70681","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T11:05:51Z","timestamp":1763377551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phenolic Extracts of Hulless Barley Grass Alleviate Progression of Colitis\u2010Related Colorectal Cancer by Inhibiting the Overexpression of Wnt\/\u03b2\u2010Catenin Signaling Pathway"],"prefix":"10.1111","volume":"90","author":[{"given":"Zhiqian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Food Science &amp; Technology School of Agriculture and Biology Shanghai Jiao Tong University  Shanghai 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