{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:07Z","timestamp":1787013727659,"version":"build-2736575974"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402088"],"award-info":[{"award-number":["32402088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study aimed to investigate the hepatoprotective effects and underlying mechanisms of a peptide\u2010plant extract combination against alcohol\u2010induced liver injury in a zebrafish model. The results demonstrate that wheat peptides (WP), soft\u2010shelled turtle peptides (STP), and\n                      <jats:italic>Pueraria lobata<\/jats:italic>\n                      root extract (PE) significantly attenuate hepatomegaly and lipid droplet accumulation, enhance the activities of acetaldehyde dehydrogenase (ALDH) and superoxide dismutase (SOD), and decrease the levels of aspartate aminotransferase (AST) and malonaldehyde (MDA). The optimal formulation ratio of WP, STP, and PE (1:4:1) is determined using fuzzy comprehensive evaluation (FSE). The combination significantly down\u2010regulated the expression of the alcohol\u2010metabolism\u2010related genes cytochrome P450 2Y3, cytochrome P450 (CYP)(\n                      <jats:italic>cyp2y3)<\/jats:italic>\n                      and cytochrome P450CYP3A65 (\n                      <jats:italic>cyp3a65)<\/jats:italic>\n                      , the fatty acid synthesis\u2010related gene acetyl\u2010CoA carboxylase 1 (\n                      <jats:italic>acc1)<\/jats:italic>\n                      , and DNA damage\u2010inducing gene 153 (GADDl53) (\n                      <jats:italic>chop)<\/jats:italic>\n                      . Furthermore, the combination improves gut microbiota diversity, increases the relative abundance of\n                      <jats:italic>Chitinilyticum<\/jats:italic>\n                      , and decreases that of\n                      <jats:italic>ZOR006<\/jats:italic>\n                      and Erysipelotrichaceae. Non\u2010targeted metabolomics analysis reveals that the hepatoprotective effect is primarily mediated through by up\u2010regulating of nucleotide and pyrimidine metabolism pathways, thereby maintaining cellular energy homeostasis. In addition, the combination up\u2010regulates ZO\u20101 and Nrf\u20102 expression, contributing to the restoration of alcohol\u2010induced intestinal barrier integrity. Collectively, the optimized peptide\u2013plant extract formulation confers significant protection against alcohol\u2010induced liver injury by modulating gut microbiota composition, re\u2010establishing hepatic metabolic homeostasis, and reinforcing intestinal barrier function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70776","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T11:55:30Z","timestamp":1768132530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic Effect of Combined Wheat Peptides, Soft\u2010Shelled Turtle Peptides and\n                    <i>Pueraria Lobata<\/i>\n                    Root Extract on Alleviating Alcoholic Liver Disease by Regulating Gut Microbiota and Intestinal Barrier"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9206-3715","authenticated-orcid":false,"given":"Hao","family":"Zhong","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hussain","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Hangzhou China"},{"name":"Moganshan Institute ZJUT  Deqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Hangzhou Kangyuan Food Science and Technology Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Rawbery Foods Biotech Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqin","family":"Feng","sequence":"additional","affiliation":[{"name":"Hangzhou Kangyuan Food Science and Technology Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-0996","authenticated-orcid":false,"given":"Rongfa","family":"Guan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Hangzhou China"},{"name":"Moganshan Institute ZJUT  Deqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/nano9010122","article-title":"Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model","volume":"9","author":"Abou\u2010Saleh H.","year":"2019","journal-title":"Nanomaterials"},{"issue":"1","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"G84","DOI":"10.1152\/ajpgi.00118.2019","article-title":"Role of Gut Microbiota in Liver Disease","volume":"318","author":"Albhaisi S. A.","year":"2020","journal-title":"American Journal of Physiology\u2010Gastrointestinal and Liver Physiology"},{"issue":"4","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, Liver Disease and the Gut Microbiota","volume":"16","author":"Bajaj J. S.","year":"2019","journal-title":"Nature Reviews Gastroenterology and Hepatology"},{"issue":"6","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"G1018","DOI":"10.1152\/ajpgi.00245.2016","article-title":"Precision Medicine in Alcoholic and Nonalcoholic Fatty Liver Disease via Modulating the Gut Microbiota","volume":"311","author":"Bluemel S.","year":"2016","journal-title":"American Journal of Physiology\u2010Gastrointestinal and Liver Physiology"},{"issue":"3","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4254\/wjh.v4.i3.81","article-title":"Alcoholic Liver Disease","volume":"4","author":"Bruha R.","year":"2012","journal-title":"World Journal of Hepatology"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1080\/21655979.2021.1982273","article-title":"Firmicutes and Blautia in Gut Microbiota Lessened in Chronic Liver Diseases and Hepatocellular Carcinoma Patients: A Pilot Study","volume":"12","author":"Chen T.","year":"2021","journal-title":"Bioengineered"},{"key":"e_1_2_9_8_1","article-title":"Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish","volume":"123","author":"Ellis J. L.","year":"2017","journal-title":"Journal of Visualized Experiments: JoVE"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152824","article-title":"A Combination of Pueraria Lobata and Silybum Marianum Protects Against Alcoholic Liver Disease in Mice","volume":"58","author":"Feng R.","year":"2019","journal-title":"Phytomedicine"},{"issue":"9","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00148-25","article-title":"Role of NLRP3 in the Metabolism of Bile Acids and Gut Microbiota in CCl4\u2010Induced Liver Fibrosis","volume":"13","author":"Feng S.","year":"2025","journal-title":"Microbiology Spectrum"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.expneurol.2017.10.004","article-title":"The Developing Utility of Zebrafish Models of Neurological and Neuropsychiatric Disorders: A Critical Review","volume":"299","author":"Fontana B. D.","year":"2018","journal-title":"Experimental Neurology"},{"issue":"2","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jhep.2018.10.008","article-title":"Hepatocellular Carcinoma in the Setting of Alcohol\u2010Related Liver Disease","volume":"70","author":"Ganne\u2010Carri\u00e9 N.","year":"2019","journal-title":"Journal of Hepatology"},{"issue":"1","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3390\/biom13010136","article-title":"Beeswax Alcohol and Fermented Black Rice Bran Synergistically Ameliorated Hepatic Injury and Dyslipidemia to Exert Antioxidant and Anti\u2010Inflammatory Activity in Ethanol\u2010Supplemented Zebrafish","volume":"13","author":"Han Y.","year":"2023","journal-title":"Biomolecules"},{"issue":"9","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1111\/jcmm.13129","article-title":"Pre\u2010Conditions for Eliminating Mitochondrial Dysfunction and Maintaining Liver Function After Hepatic Ischaemia Reperfusion","volume":"21","author":"Hu C.","year":"2017","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104501","article-title":"Natural Products, Extracts and Formulations Comprehensive Therapy for the Improvement of Motor Function in Alcoholic Liver Disease","volume":"150","author":"Hu S.","year":"2019","journal-title":"Pharmacological Research"},{"issue":"2","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jhep.2018.10.036","article-title":"Treating Alcohol\u2010Related Liver Disease From a Public Health Perspective","volume":"70","author":"Hydes T.","year":"2019","journal-title":"Journal of Hepatology"},{"issue":"1","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23469-2","article-title":"Lentinan Improves Intestinal Inflammation and Gut Dysbiosis in Antibiotics\u2010Induced Mice","volume":"12","author":"Ji X.","year":"2022","journal-title":"Scientific Reports"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.727937","article-title":"Tumor\u2010Associated Microbiota in Proximal and Distal Colorectal Cancer and Their Relationships With Clinical Outcomes","volume":"12","author":"Jin M.","year":"2021","journal-title":"Frontiers in Microbiology"},{"issue":"16","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.3390\/jcm12165244","article-title":"Effects of Plant\u2010Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double\u2010Blind, Paralleled, Placebo\u2010Controlled Clinical Trial","volume":"12","author":"Jung S. H.","year":"2023","journal-title":"Journal of Clinical Medicine"},{"issue":"2","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3892\/ijmm.2016.2831","article-title":"Wheat\u2010Bran Autolytic Peptides Containing a Branched\u2010Chain Amino Acid Attenuate Non\u2010Alcoholic Steatohepatitis via the Suppression of Oxidative Stress and the Upregulation of AMPK\/ACC in High\u2010Fat Diet\u2010Fed Mice","volume":"39","author":"Kawaguchi T.","year":"2017","journal-title":"International Journal of Molecular Medicine"},{"issue":"19","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1016\/j.cell.2022.08.005","article-title":"Microbiota Imbalance Induced by Dietary Sugar Disrupts Immune\u2010Mediated Protection From Metabolic Syndrome","volume":"185","author":"Kawano Y.","year":"2022","journal-title":"Cell"},{"issue":"1","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1572-0241.1999.00797.x","article-title":"Leaky Gut in Alcoholic Cirrhosis: A Possible Mechanism for Alcohol\u2010Induced Liver Damage","volume":"94","author":"Keshavarzian A.","year":"1999","journal-title":"Official Journal of the American College of Gastroenterology| ACG"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.869250","article-title":"Probiotic Lactobacilli Ameliorate Alcohol\u2010Induced Hepatic Damage via Gut Microbial Alteration","volume":"13","author":"Kim J.","year":"2022","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3748\/wjg.v22.i1.8","article-title":"Optimal Management for Alcoholic Liver Disease: Conventional Medications, Natural Therapy or Combination?","volume":"22","author":"Kim M.\u2010S.","year":"2016","journal-title":"World Journal of Gastroenterology"},{"issue":"5","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2131\/jts.44.347","article-title":"Transcriptional Profiling of Cytochrome P450 Genes in the Liver of Adult Zebrafish, Danio Rerio","volume":"44","author":"Kubota A.","year":"2019","journal-title":"The Journal of Toxicological Sciences"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/B978-0-444-63504-4.00013-X","volume-title":"New and Future Developments in Microbial Biotechnology and Bioengineering","author":"Kumar P.","year":"2019"},{"issue":"9","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/jgh.17038","article-title":"Compositional and Metabolomic Shifts of the Gut Microbiome in Alcohol\u2010Related Liver Disease","volume":"40","author":"Kuo C. H.","year":"2025","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2025.1670769","article-title":"Excessive Alcohol Consumption: A Driver of Metabolic Dysfunction and Inflammation","volume":"7","author":"Lee J.","year":"2025","journal-title":"Frontiers in Toxicology"},{"issue":"1","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/acs.jafc.0c06346","article-title":"Lactobacillus Plantarum KLDS1. 0344 and Lactobacillus Acidophilus KLDS1. 0901 Mixture Prevents Chronic Alcoholic Liver Injury in Mice by Protecting the Intestinal Barrier and Regulating Gut Microbiota and Liver\u2010Related Pathways","volume":"69","author":"Li H.","year":"2020","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"9","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.3390\/molecules27092675","article-title":"Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides","volume":"27","author":"Li X.","year":"2022","journal-title":"Molecules"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106768","article-title":"Effects of Lead Contamination on Histology, Antioxidant and Intestinal Microbiota Responses in Freshwater Crayfish","volume":"265","author":"Li Y.","year":"2023","journal-title":"Procambarus Clarkii Aquatic Toxicology"},{"issue":"34","key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1021\/acs.jafc.0c04055","article-title":"Efficient One\u2010Pot Synthesis of Cytidine 5\u2032\u2010Monophosphate Using an Extremophilic Enzyme Cascade System","volume":"68","author":"Li Z.","year":"2020","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"8","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1111\/acer.12483","article-title":"Micro\u2010RNA\u2010155 Deficiency Prevents Alcohol\u2010Induced Serum Endotoxin Increase and Small Bowel Inflammation in Mice","volume":"38","author":"Lippai D.","year":"2014","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111121","article-title":"Puerariae Lobatae Radix Flavonoids and Puerarin Alleviate Alcoholic Liver Injury in Zebrafish by Regulating Alcohol and Lipid Metabolism","volume":"134","author":"Liu Y.\u2010S.","year":"2021","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"3","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcmgh.2015.04.003","article-title":"The Gut Microbiota and Liver Disease","volume":"1","author":"Llorente C.","year":"2015","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"issue":"3","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.pbb.2004.01.003","article-title":"Acute Effects of Alcohol on Larval Zebrafish: a Genetic System for Large\u2010Scale Screening","volume":"77","author":"Lockwood B.","year":"2004","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112687","article-title":"Compound\u2010Based Chinese Medicine Formula: From Discovery to Compatibility Mechanism","volume":"254","author":"Luan X.","year":"2020","journal-title":"Journal of Ethnopharmacology"},{"issue":"4","key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","article-title":"Endoplasmic Reticulum Stress in Liver Disease","volume":"54","author":"Malhi H.","year":"2011","journal-title":"Journal of Hepatology"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113303","article-title":"The Food Plant Silybum Marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and Clinical Evidence","volume":"265","author":"Marmouzi I.","year":"2021","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"e_1_2_9_40_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96432-2","article-title":"Biochemical Elucidation of Citrate Accumulation in Synechocystis sp. PCC 6803 via Kinetic Analysis of Aconitase","volume":"11","author":"Nishii M.","year":"2021","journal-title":"Scientific Reports"},{"issue":"11","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/antiox13111293","article-title":"Non\u2010Targeted Metabolomics Reveal Apomorphine's Therapeutic Effects and Lysophospholipid Alterations in Steatohepatitis","volume":"13","author":"Ogiso H.","year":"2024","journal-title":"Antioxidants"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112353","article-title":"Transcriptome Analysis Reveals the Hepatoprotective Mechanism of Soybean Meal Peptides Against Alcohol\u2010Induced Acute Liver Injury Mice","volume":"154","author":"Pan F.","year":"2021","journal-title":"Food and Chemical Toxicology"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2019.108887","article-title":"Characterization and Production of Novel Antioxidative Peptides Derived From Fermented Goat Milk by L. fermentum","volume":"119","author":"Panchal G.","year":"2020","journal-title":"LWT"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.715611","article-title":"Role of Barrier Integrity and Dysfunctions in Maintaining the Healthy Gut and Their Health Outcomes","volume":"12","author":"Panwar S.","year":"2021","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109179","article-title":"Low Dose of Chronic Ethanol Exposure in Adult Zebrafish Induces Hepatic Steatosis and Injury","volume":"117","author":"Park K.\u2010H.","year":"2019","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110836","article-title":"Adult Zebrafish as an in Vivo Drug Testing Model for Ethanol Induced Acute Hepatic Injury","volume":"132","author":"Park K.\u2010H.","year":"2020","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.phymed.2018.09.209","article-title":"Semen Hoveniae Extract Ameliorates Alcohol\u2010Induced Chronic Liver Damage in Rats via Modulation of the Abnormalities of Gut\u2010Liver Axis","volume":"52","author":"Qiu P.","year":"2019","journal-title":"Phytomedicine"},{"issue":"34","key":"e_1_2_9_48_1","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.11103","article-title":"Binge Ethanol Exposure Causes Endoplasmic Reticulum Stress, Oxidative Stress and Tissue Injury in the Pancreas","volume":"7","author":"Ren Z.","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00204-021-03064-6","article-title":"Chronic Intestinal Inflammation Drives Colorectal Tumor Formation Triggered by Dietary Heme Iron in Vivo","volume":"95","author":"Seiwert N.","year":"2021","journal-title":"Archives of Toxicology"},{"issue":"5","key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.clinthera.2022.04.012","article-title":"Nutrition as Therapy in Liver Disease","volume":"44","author":"Shah N. D.","year":"2022","journal-title":"Clinical Therapeutics"},{"issue":"11","key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/liv.15716","article-title":"Investigating the Role of Lipid Genes in Liver Disease Using Fatty Liver Models of Alcohol and High Fat in Zebrafish (Danio Rerio)","volume":"43","author":"Shihana F.","year":"2023","journal-title":"Liver International"},{"issue":"5","key":"e_1_2_9_52_1","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1007\/s10462-022-10282-6","article-title":"Setback in Ranking Fuzzy Numbers: a Study in Fuzzy Risk Analysis in Diabetes Prediction","volume":"56","author":"Sotoudeh\u2010Anvari M.","year":"2023","journal-title":"Artificial Intelligence Review"},{"key":"e_1_2_9_53_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.854879","article-title":"Therapeutic Potential of Natural Plants Against Non\u2010Alcoholic Fatty Liver Disease: Targeting the Interplay Between Gut Microbiota and Bile Acids","volume":"12","author":"Sun Q.","year":"2022","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"1","key":"e_1_2_9_54_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/00952990.2016.1217539","article-title":"Establishment of an Alcoholic Fatty Liver Disease Model in Mice","volume":"43","author":"Tan P.","year":"2017","journal-title":"The American Journal of Drug and Alcohol Abuse"},{"issue":"4","key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/biomedicines6040106","article-title":"Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects","volume":"6","author":"Teschke R.","year":"2018","journal-title":"Biomedicines"},{"issue":"7","key":"e_1_2_9_56_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","article-title":"The Gut\u2013Liver Axis and the Intersection With the Microbiome","volume":"15","author":"Tripathi A.","year":"2018","journal-title":"Nature Reviews Gastroenterology and Hepatology"},{"issue":"5","key":"e_1_2_9_57_1","first-page":"1213","article-title":"Ethanol Metabolism and Oxidative Stress are Required for Unfolded Protein Response Activation and Steatosis in Zebrafish With Alcoholic Liver Disease","volume":"6","author":"Tsedensodnom O.","year":"2013","journal-title":"Disease Models and Mechanisms"},{"issue":"10","key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jnutbio.2012.03.005","article-title":"The Nrf2\u2010Antioxidant Response Element Pathway: A Target for Regulating Energy Metabolism","volume":"23","author":"Vomhof\u2010DeKrey E. E.","year":"2012","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"e_1_2_9_59_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107351","article-title":"Aberrant Hepatic Lipid Metabolism Associated With Gut Microbiota Dysbiosis Triggers Hepatotoxicity of Novel PFOS Alternatives in Adult Zebrafish","volume":"166","author":"Wang Q.","year":"2022","journal-title":"Environment International"},{"issue":"15","key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.3390\/ijms23158081","article-title":"Hepatoprotective Effect of Oyster Peptide on Alcohol\u2010Induced Liver Disease in Mice","volume":"23","author":"Wang X.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"19","key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.3390\/foods11193014","article-title":"Protective Effects of Several Common Amino Acids, Vitamins, Organic Acids, Flavonoids and Phenolic Acids Against Hepatocyte Damage Caused by Alcohol","volume":"11","author":"Wang Y.","year":"2022","journal-title":"Foods"},{"issue":"11","key":"e_1_2_9_62_1","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1111\/acer.14944","article-title":"Analysis of Alcohol Use, Consumption of Micronutrient and Macronutrients, and Liver Health in the 2017\u20132018 National Health and Nutrition Examination Survey","volume":"46","author":"Warner J. B.","year":"2022","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.109638","article-title":"Ethanol Metabolism: The Good, the Bad, and the Ugly","volume":"140","author":"Wilson D. F.","year":"2020","journal-title":"Medical Hypotheses"},{"issue":"44","key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"9675","DOI":"10.1021\/acs.jafc.7b03791","article-title":"Lychee (Litchi Chinensis Sonn.) Pulp Phenolic Extract Provides Protection Against Alcoholic Liver Injury in Mice by Alleviating Intestinal Microbiota Dysbiosis, Intestinal Barrier Dysfunction, and Liver Inflammation","volume":"65","author":"Xiao J.","year":"2017","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"18","key":"e_1_2_9_65_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810385","article-title":"Insight Into Lotusine and Puerarin in Repairing Alcohol\u2010Induced Metabolic Disorder Based on uplc\u2010ms\/Ms","volume":"23","author":"Xu J.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"e_1_2_9_66_1","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1002\/fsn3.1182","article-title":"Study on the Synergistic Protective Effect of Lycium Barbarum L. Polysaccharides and Zinc Sulfate on Chronic Alcoholic Liver Injury in Rats","volume":"7","author":"Yan Y.","year":"2019","journal-title":"Food Science and Nutrition"},{"key":"e_1_2_9_67_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112240","article-title":"Wheat Embryo Globulin Protects Against Acute Alcohol\u2010Induced Liver Injury in Mice","volume":"153","author":"Yang C.","year":"2021","journal-title":"Food and Chemical Toxicology"},{"issue":"30","key":"e_1_2_9_68_1","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1080\/10408398.2025.2455954","article-title":"Regulatory Mechanisms of the Probiotic\u2010Targeted Gut\u2013Liver Axis for the Alleviation of Alcohol\u2010Related Liver Disease: A Review","volume":"65","author":"Yang F.","year":"2025","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"e_1_2_9_69_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1113789","article-title":"Association Between Daidzein Intake and Metabolic Associated Fatty Liver Disease: A Cross\u2010Sectional Study From NHANES 2017\u20132018","volume":"10","author":"Yang Z.","year":"2023","journal-title":"Frontiers in Nutrition"},{"issue":"9","key":"e_1_2_9_70_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1875-5364(23)60399-1","article-title":"Puerarin Inhibits Inflammation and Lipid Accumulation in Alcoholic Liver Disease Through Regulating MMP8","volume":"21","author":"Ying H.","year":"2023","journal-title":"Chinese Journal of Natural Medicines"},{"issue":"12","key":"e_1_2_9_71_1","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1111\/1750-3841.13953","article-title":"Hepatoprotective Effect of Albumin Peptides From Corn Germ Meal on Chronic Alcohol\u2010Induced Liver Injury in Mice","volume":"82","author":"Yu Y.","year":"2017","journal-title":"Journal of Food Science"},{"issue":"8","key":"e_1_2_9_72_1","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3390\/antiox13081012","article-title":"Mechanism of Action and Therapeutic Implications of Nrf2\/HO\u20101 in Inflammatory Bowel Disease","volume":"13","author":"Yuan L.","year":"2024","journal-title":"Antioxidants"},{"issue":"11","key":"e_1_2_9_73_1","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.626","article-title":"New Focuses on Roles of Communications Between Endoplasmic Reticulum and Mitochondria in Identification of Biomarkers and Targets","volume":"11","author":"Zhang L.","year":"2021","journal-title":"Clinical and Translational Medicine"},{"issue":"16","key":"e_1_2_9_74_1","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1021\/acs.jafc.2c00744","article-title":"Protective Effect and Mechanism of Plant\u2010Based Monoterpenoids in Non\u2010Alcoholic Fatty Liver Diseases","volume":"70","author":"Zhang W.","year":"2022","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"11","key":"e_1_2_9_75_1","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.3390\/nu10111754","article-title":"Protective Effects of Five Structurally Diverse Flavonoid Subgroups Against Chronic Alcohol\u2010Induced Hepatic Damage in a Mouse Model","volume":"10","author":"Zhao L.","year":"2018","journal-title":"Nutrients"},{"issue":"5","key":"e_1_2_9_76_1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3390\/nu15051229","article-title":"Lutein Prevents Liver Injury and Intestinal Barrier Dysfunction in Rats Subjected to Chronic Alcohol Intake","volume":"15","author":"Zhao S.","year":"2023","journal-title":"Nutrients"},{"issue":"20","key":"e_1_2_9_77_1","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1093\/jxb\/erab361","article-title":"The Proline Cycle as an Eukaryotic Redox Valve","volume":"72","author":"Zheng Y.","year":"2021","journal-title":"Journal of Experimental Botany"},{"issue":"4","key":"e_1_2_9_78_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3390\/foods11040600","article-title":"Soft\u2010Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice","volume":"11","author":"Zhong H.","year":"2022","journal-title":"Foods"},{"issue":"3","key":"e_1_2_9_79_1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1039\/D0FO02768E","article-title":"Advances in the Preparation and Assessment of the Biological Activities of Chitosan Oligosaccharides With Different Structural Characteristics","volume":"12","author":"Zhou J.","year":"2021","journal-title":"Food and Function"},{"key":"e_1_2_9_80_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.826204","article-title":"The Nrf2 Pathway in Liver Diseases","volume":"10","author":"Zhou J.","year":"2022","journal-title":"Frontiers in Cell and Developmental Biology"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.70776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T11:55:39Z","timestamp":1768132539000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.70776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1750-3841.70776"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.70776","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70776"}}