{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:54:06Z","timestamp":1793213646385,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The presence of pesticide residues in honey represents a significant concern for food safety and public health, underscoring the need for advanced analytical techniques capable of ensuring accurate detection and effective food control. In this study, a stereolithographically 3D\u2010printed device coated with the solid\u2010phase extraction (SPE) sorbent Oasis MCX was developed for the ultrasound\u2010assisted extraction (UAE) of pesticide residues in honey, followed by ultra\u2010high performance liquid chromatography with diode array detection (UHPLC\u2010DAD) analysis. Variables that affect the performance of the 3D\u2010printed extraction (i.e., design and fabrication of 3D\u2010printed device, SPE resin, elution solution, pH, and ultrasonic conditions) and the chromatographic analysis were systematically evaluated. The optimized methodology allowed the simultaneous determination of five pesticides: azoxystrobin (AZO), carbaryl (CAR), pirimicarb (PIR), thiacloprid (THC), and thiamethoxam (THI). Chromatographic separation was completed in less than 15 min using a KinetexXB\u2010C18 column (2.6\u00a0\u00b5m, 100\u00a0\u00c5, 100\u00a0\u00d7\u00a03\u00a0mm), with a mobile phase consisting of methanol and 0.1% formic acid (pH 3.35). The proposed methodology showed satisfactory agreement compared with commercial QuEChERS dispersive SPE kits. The developed method demonstrated good linearity up to 100 mg L\n                      <jats:sup>\u22121<\/jats:sup>\n                      (\n                      <jats:italic>\n                        R\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      \u00a0&gt;\u00a00.99), low detection limits (0.002\u20130.5 mg kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), good precision (&lt; 5.1 % RSD), and satisfactory recoveries (90\u2013109 %). Its successful application to real honey samples demonstrates the method's potential for reliable multi\u2010residue pesticide analysis in complex food matrices. The sample preparation stage was evaluated with the AGREEprep tool, yielding a greenness score of 0.43, which indicates a moderately green performance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70788","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:02:16Z","timestamp":1766991736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasound\u2010Assisted Extraction Using a 3D\u2010Printed Device Functionalized With SPE Sorbent for UHPLC\u2010DAD Analysis of Pesticide Residues in Honey"],"prefix":"10.1111","volume":"91","author":[{"given":"Daniela","family":"Lupu","sequence":"first","affiliation":[{"name":"Environmental Analytical Chemistry Group University of the Balearic Islands  Palma Spain"},{"name":"Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy Science and Technology of T\u00e2rgu Mures  T\u00e2rgu Mures Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Hancu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy Science and Technology of T\u00e2rgu Mures  T\u00e2rgu Mures Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-248X","authenticated-orcid":false,"given":"Laura","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Environmental Analytical Chemistry Group University of the Balearic Islands  Palma 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Environment Agency.2023. \u201cHow Pesticides Impact Human Health and Ecosystems in Europe.\u201d Briefing no. 06\/2023.https:\/\/doi.org\/10.2800\/760240."},{"key":"e_1_2_8_20_1","unstructured":"European Union Reference Laboratories (EURL).2026.Analytical quality control and method validation procedures for pesticide residues analysis in food and feed (SANTE\/11312\/2021 v2026)."},{"key":"e_1_2_8_21_1","unstructured":"FAO\/WHO Codex Alimentarius Commission.2024. \u201cMaximum Residue Limits (MRLs) and Risk Management Recommendations (RMRs) for Residues of Veterinary Drugs in Foods (CXM 2\u20132024).\u201dFood and Agriculture 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