{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T17:10:31Z","timestamp":1767546631278,"version":"3.48.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Skeletal muscle atrophy triggered by glucocorticoid is linked to impaired mitochondrial function and dysregulated protein metabolism. While the metabolic benefits of sweet potato roots have been widely studied, the anti\u2010atrophic potential of their edible aerial parts on the muscle remains unexplored. This study examined the protective role of an aqueous extract of Tongchaeru aerial parts (TE), a sweet potato cultivar newly developed in Korea. The major phenolic compounds in TE were estimated using UPLC. Male mice were received dexamethasone (Dex, 10\u00a0mg\/kg body weight) to trigger muscle atrophy and co\u2010treated orally with TE at doses of 200 or 400\u00a0mg\/kg for 14 days. Grip strength (GS), muscle histology, markers of mitochondrial biogenesis and respiratory complexes, and protein metabolic signaling pathways were evaluated. TE significantly improved GS and increased the cross\u2010sectional area of the quadriceps and gastrocnemius muscles. TE reversed Dex\u2010mediated downregulation of mitochondrial biogenesis\u2010associated biomolecules (PGC\u20101\u03b1, NRF1, and TFAM) and restored the expression of oxidative phosphorylation (OXPHOS) components. TE attenuated AMPK\u2010FoxO3\u03b1 activation and reduced the expression of muscle degradation\u2010related factors, including atrogin\u20101, MuRF1, and myostatin, while counteracting Dex\u2010induced suppression of the PI3K\u2010Akt\u2010mTOR signaling pathway and muscle protein synthesis markers (MyoD1, MyoG, and MHC). Phenolic profiling revealed that TE contains high levels of neochlorogenic acid, chlorogenic acid, and caffeic acid. These findings suggest that TE mitigates Dex\u2010induced skeletal muscle atrophy by restoring mitochondrial function, reducing protein degradation, and maintaining protein synthesis. TE may act as a nutraceutical with preventive effects on muscle wasting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70804","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T17:05:38Z","timestamp":1767546338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extract of Aerial Parts of \u201cTongchaeru\u201d Sweet Potato Attenuates Muscle Atrophy via Mitochondrial Improvement and PI3K\u2010Akt Pathway Activation in a Mouse Model"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-5295","authenticated-orcid":false,"given":"Mi Ja","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food Sciences Fermented and Processed Food Research Division, National Institute of Crop and Food Science Rural Development Administration (RDA)  Wanju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Sunchon National University  Suncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u2010Yeong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biology, National Institute of Agricultural Sciences Rural Development Administration  Wanju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se\u2010Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"BIO Center Chungbuk Technopark  Ochang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song Yie","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food Sciences Fermented and Processed Food Research Division, National Institute of Crop and Food Science Rural Development Administration (RDA)  Wanju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Bin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food Sciences Fermented and Processed Food Research Division, National Institute of Crop and Food Science Rural Development Administration (RDA)  Wanju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeoun Suk","family":"Cho","sequence":"additional","affiliation":[{"name":"Reclaimed Land Agriculture Research Team, National Institute of Crop and Food Science Rural Development Administration (RDA)  Wanju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae\u2010In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Sunchon National University  Suncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Sunchon National University  Suncheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00204.2014"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.09.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27061884"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116556"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10040588"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5536\/kjps.2023.50.4.325"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.9799\/ksfan.2024.37.6.428"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00516"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071820"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164887"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.036"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"23","article-title":"Chlorogenic Acid Ameliorates Muscle Wasting by Upregulating mRNA Expressions of Calcineurin and PGC\u20101\u03b1 in Diabetic Rat Model","volume":"79","author":"Siwi K.","year":"2024","journal-title":"Supplement, Medical Journal of Malaysia"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(04)00211\u20104"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1270\/jsbbs.67.1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c03967"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.70804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T17:05:40Z","timestamp":1767546340000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.70804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/1750-3841.70804"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.70804","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70804"}}