{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T08:50:27Z","timestamp":1775897427749,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Previous studies have found that gut flora, immunity, and neuroinflammation play key roles in the pathogenesis of depression, and fatty acids are neuroprotective. The present study aimed to reveal the effects of capric acid intake (absorbed in the colon via resistant starch complex) on LPS\u2010induced depression\u2010like behavior and its underlying mechanisms. Male ICR mice were ingested with resistant starch\u2010decanoic acid complex (RS\u2010FA, 13\u00a0g\/kg) for 50 consecutive days. The depression model was established by injecting LPS (0.5\u00a0mg\/kg every two days for three injections). The results of behavioral tests showed that the mice pretreated with resistant starch capric acid complex had significantly shorter resting time in the tail suspension test (TST); the number of crossing grids and the number of standing in the open field test (OFT) were significantly increased. In addition, TNF\u2010\u03b1 levels in the serum of depressed mice were decreased; 5\u2010HT levels in the hippocampus were increased. It had an ameliorative effect on the haphazard arrangement of colonic glandular cells caused by LPS, as well as nuclear condensation and eosinophilic degeneration of hippocampal neurons. 16S rRNA analysis revealed that pretreatment with resistant starch\u2010capric acid complexes reversed depression\u2010associated dysbiosis, restoring gut microbial composition to levels approaching those of the control group. Restores uniformity in the animal gut microbiota, increases beneficial bacterial populations, and demonstrates efficacy in elevating short\u2010chain fatty acid levels. Furthermore, resistant starch\u2010capric acid concurrently modulates the TLR4\/NF\u2010\u03baB signaling pathway and the tryptophan metabolic pathway to regulate gut microbiota dysbiosis in depressed mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70818","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:54:06Z","timestamp":1772970846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resistant Starch\u2010Capric Acid Effectively Improves Lipopolysaccharide\u2010Induced Depressive Behavior by Protecting the Intestinal Microbiota Barrier and Inhibiting Inflammatory Responses"],"prefix":"10.1111","volume":"91","author":[{"given":"Yining","family":"Yang","sequence":"first","affiliation":[{"name":"College of Animal Medicine Sichuan Agricultural University  Yaan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2424-5483","authenticated-orcid":false,"given":"Yuanyuan","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqian","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiling","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Food and Biochemical Engineering Yantai Vocational College  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13101461"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00457"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.034"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"203","article-title":"The Gut\u2010Brain Axis: Interactions Between Enteric Microbiota, Central and Enteric Nervous Systems","volume":"28","author":"Carabotti M.","year":"2015","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr254"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.224"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.09.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9112402"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04097"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10517"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2022.110927"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.08.218"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2023.109228"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(18)30511\u2010X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2016.02.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.06.016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c04290"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","unstructured":"Lu C. 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