{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T13:22:34Z","timestamp":1768137754614,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The aim of this study was to explore the effects of\n                      <jats:italic>Lacticaseibacillus rhamnosu<\/jats:italic>\n                      AFY02 (LR\u2010AFY02), which was obtained from traditional fermented yogurt, on mice with inflammation\u2010related AOM\/DSS\u2010induced colon cancer and the associated processes. The pathological results of the colon tissue of mice, the indicators of serum and tissue, and their expressions in the tissue were detected. The results showed that the use of LR\u2010AFY02 significantly improved intestinal histopathological injury, decreased the incidence of intestinal tumors, downregulated the expression of I\u03baB\u03b2, p65, p50, p52, Bcl\u20102, and Bcl\u2010xL in colon tissue, and increased the expression of Bid and caspase\u20108 in colon tissue. Compared with the model group, high concentration LR\u2010AFY02H could reduce IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1, NF\u2010\u03baB, and iNOS cytokine levels in serum and colon tissue. The ability to downregulate these cytokines was close to that of aspirin and stronger than that of low concentration LR\u2010AFY02L. By controlling the NF\u2010\u03baB and apoptosis pathways, LR\u2010AFY02 can help reduce intestinal inflammation and prevent the growth of intestinal tumors. These findings suggested that LR\u2010AFY02 may have regulatory effects on colon cancer in mice and merits additional study.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70852","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T10:38:12Z","timestamp":1768127892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of\n                    <i>Lacticaseibacillus Rhamnosu<\/i>\n                    AFY02 on AOM\/DSS\u2010Induced Inflammation\u2010Associated Colon Cancer in Mice and the Mechanism"],"prefix":"10.1111","volume":"91","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Environment and Quality Inspection College Chongqing Chemical Industry Vocational College  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Shen","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital &amp; Chongqing Cancer Institute &amp; Chongqing Cancer Hospital  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehan","family":"Luo","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center for Child Nutrition and Health Development Chongqing University of Education  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongpeng","family":"He","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital &amp; Chongqing Cancer Institute &amp; Chongqing Cancer Hospital  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital &amp; Chongqing Cancer Institute &amp; Chongqing Cancer Hospital  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tenghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing China Testing International Testing Technology Co., Ltd.  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