{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:26:55Z","timestamp":1788316015972,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The immune system plays a crucial role in protecting the body against infections, and its suppression can lead to severe complications during chemotherapy. Bee products are rich in bioactive phenolic compounds with antioxidant and immunomodulatory properties. This study aimed to characterize the phenolic composition of Moroccan honey, bee pollen, and propolis and to evaluate their potential, individually and in combination, to counteract CTX\u2010induced immunosuppression in mice. Phenolic compounds were analyzed by HPLC\u2010DAD, total phenolics, and flavonoids were quantified using colorimetric assays, and antioxidant activity was determined by DPPH, RP, and TAC methods. In vivo, CTX\u2010induced immunocompromised mice were distributed into six groups and treated orally for 21 days with honey (1 g\/kg), bee pollen (100 mg\/kg), propolis (100 mg\/kg), or their mixture at a volume ratio of 1:1:1 (v\/v\/v). Results showed that propolis had the highest total phenolic and flavonoid content and exhibited the strongest antioxidant activity. All bee products significantly improved leukocyte counts, thymus and spleen indices, IgG\/IgM levels, and delayed hypersensitivity response compared with the CTX non\u2010treated group, with propolis, bee pollen, and the mixture showing the most pronounced effects. Molecular docking revealed strong interactions of major phenolics (apigenin, kaempferol, isorhamnetin, pinocembrin) with immune\u2010related proteins (STAT3, JNK, and SYK), suggesting a multi\u2010target mechanism of immunoprotection. These findings highlight Moroccan bee products as promising natural adjuvants for supporting immune function during chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70877","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:21:42Z","timestamp":1768987302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antioxidant and Immunoprotective Effects of Moroccan Honey, Bee Pollen, and Propolis Against Cyclophosphamide\u2010Induced Immunosuppression in Mice: In Vitro, In Vivo, and In Silico Insights"],"prefix":"10.1111","volume":"91","author":[{"given":"Karima","family":"El\u2010yagoubi","sequence":"first","affiliation":[{"name":"Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz University Sidi Mohamed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"El ouassete","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najoua","family":"Soulo","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology, Conservation, and Valorisation of Bioresources (LBCVB), Faculty of Sciences Dhar El Mahraz University Sidi Mohamed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marouane","family":"Aouji","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Resources and Sustainable Development Ibn Tofail University  Kenitra Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Touzani","sequence":"additional","affiliation":[{"name":"Laboratory of Mini\u2010Invasive Surgery, Robotic Surgery, Artificial Intelligence, and Educational Innovations (MIRIIL), Faculty of Medicine, Pharmacy and Dental Medicine University Sidi Mohamed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-6558","authenticated-orcid":false,"given":"Badiaa","family":"Lyoussi","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz University Sidi Mohamed Ben Abdellah  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120354"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"13","article-title":"An In\u2010Silico Analysis of the Targeting of Cyclooxygenase\u20102, Lipoxygenases, and Glutathione S\u2010Transferase, Major Components of the Flesh of the Snail Helix Aspersa M\u00fcller, Using a Molecular Docking: Research Focused on Colorectal Cancer","volume":"15","author":"Aouji M.","year":"2025","journal-title":"Biointerface Research in Applied Chemistry"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5560182"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5772\/1864"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO01008E"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111775"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00110.2009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1713"},{"issue":"2","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/fsn3.2038","article-title":"Konjac Glucomannan From Amorphophallus Konjac Enhances Immunocompetence of the 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