{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:13:48Z","timestamp":1790039628395,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["(202302AE090021)"],"award-info":[{"award-number":["(202302AE090021)"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Type 2 diabetes mellitus (T2DM), one of the most rapidly growing metabolic disorders globally, poses a substantial public health burden. In this study, a novel edible eutectogel was innovatively developed for the co\u2010delivery of natural active ingredients, baicalein (Bai), and 1\u2010deoxynojirimycin (DNJ). Utilizing a deep eutectic solvent (DES) system, the hydrophobic Bai and hydrophilic DNJ were co\u2010dissolved and encapsulated within the eutectogel (Bai\u2010DNJ\/EG), enabling gastric protection and targeted intestinal release. Animal experimental demonstrated that the Bai\u2010DNJ\/EG significantly ameliorated multiple pathological features, including blood glucose reduction, improved insulin sensitivity, attenuated systemic inflammation, decreased fat accumulation, and mitigated organ damage. Compared with Bai\/EG and DNJ\/EG, Bai\u2010DNJ\/EG exhibited superior therapeutic efficacy across all parameters, indicating a synergistic effect between the Bai and DNJ. The dose of Bai in Bai\u2010DNJ\/EG was reduced by 50% relative to previous studies, and DNJ was 7.5 times less than that of clinical use in a Chinese herbal preparation for lowering blood glucose. In addition, comparison of lipid metabolism and inflammatory factors between Bai HG and Bai\/EG groups indicated that DES enhanced the pharmacological activity of Bai by improving its solubility. Furthermore, 16S rRNA sequencing revealed that Bai\u2010DNJ\/EG positively regulates gut microbiota homeostasis and repairs the intestinal barrier. Bai\u2010DNJ\/EG inhibited deleterious bacteria including Methanobacteriaceae,\n                      <jats:italic>Pseudomonadota<\/jats:italic>\n                      ,\n                      <jats:italic>Campylobacterota<\/jats:italic>\n                      , and\n                      <jats:italic>Spirochaetota<\/jats:italic>\n                      , while promoted the SCFA\u2010producing bacteria, for example, Muribaculaceae and Butyricicoccaceae. This study presents a groundbreaking strategy for the synergistic delivery of natural bioactives and establishes a new paradigm for modernized traditional natural medicine formulations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70878","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:33:54Z","timestamp":1769855634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Edible Eutectogel Containing Baicalein and 1\u2010Deoxynojirimycin Alleviates Type 2 Diabetes Mellitus"],"prefix":"10.1111","volume":"91","author":[{"given":"Naijun","family":"Dong","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Intelligent Bio\u2010Manufacturing, School of Bioengineering Dalian University of Technology  Dalian 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