{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:52:05Z","timestamp":1779083525223,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                    <jats:p>\n                      A rapid and sensitive surface\u2010enhanced Raman spectroscopy (SERS) method combined with partial least squares (PLS) and linear regression models were developed for detecting etomidate in aquatic products. This study compared the performance of three nanoparticle substrates: silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and gold\u2010core silver\u2010shell nanoparticles (Au@AgNPs), with Au@AgNPs showing the highest enhancement factor (EF) of 2231, a limit of detection (LOD) of 0.1\u00a0ng\/mL, and a limit of quantification (LOQ) of 0.5\u00a0ng\/mL. The optimal substrate was identified as Au@AgNPs. Furthermore, the binding conditions for etomidate were optimized. The PLS model was constructed using seven latent variables (LVs), used first derivative (FD)\u00a0+\u00a0straight\u2010line subtraction (SLS) preprocessing, and a spectral region of 955\u20131710\u00a0cm\n                      <jats:sup>\u22121<\/jats:sup>\n                      , with\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>C<\/jats:sub>\n                      of 0.9831 and\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>P<\/jats:sub>\n                      of 0.9517. The SERS method was validated in real samples, showing high accuracy and sensitivity, and a lower detection limit than HPLC. This method is valuable for ensuring seafood safety.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70884","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:11:42Z","timestamp":1772971902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Method Study on Determination of Etomidate in Aquatic Products by Chemometrics Combined With SERS"],"prefix":"10.1111","volume":"91","author":[{"given":"Xue","family":"Ming","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Ying","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningbo University  Ningbo 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