{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:31:09Z","timestamp":1793338269762,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Ultrasound\u2010assisted extraction (UAE) is increasingly recognized as an effective process intensification strategy for phytochemical recovery; however, its optimization is often treated empirically, with limited mechanistic insight into solvent\u2013cavitation interactions. In this study, a mechanistically informed and statistically optimized UAE approach was developed for ginger rhizome using environmentally benign ethanol\u2013water solvent systems. A Box\u2013Behnken design was employed to simultaneously evaluate the effects of ginger\u2010to\u2010solvent ratio, solvent composition, and extraction time on extraction yield, antioxidant activity (DPPH, ABTS, Phenanthroline, and CUPRAC assays), total phenolic content (TPC), and flavonol content (FC). The developed response surface models exhibited strong predictive performance, yielding an optimized extraction yield of 33.22%. Notably, solvent composition emerged as the dominant factor, with water\u2010rich systems enhancing oil yield through intensified cavitation and matrix hydration effects, rather than solubility\u2010driven mechanisms alone. Under optimized conditions, antioxidant activities of 27.06, 4.42, 3.59, and 4.70\u00a0\u00b5g\/mL were obtained, alongside TPC and FC values of 79.67\u00a0mg GAE\/g and 3.38\u00a0mg QE\/g, respectively. GC\u2013Q\u2010TOF\u2010MS analysis of extracts obtained with 0%, 50%, and 100% ethanol identified 11 major phenolic compounds, revealing solvent\u2010dependent selectivity toward key bioactives. A direct comparison with Soxhlet extraction, optimized using the same RSM framework, confirmed that UAE significantly improves extraction efficiency and bioactivity retention while reducing extraction time and solvent consumption. Overall, this work provides both mechanistic understanding and practical optimization guidelines, supporting UAE as a scalable and sustainable extraction platform for food, pharmaceutical, and cosmetic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.70947","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:56:34Z","timestamp":1773482194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acoustic Cavitation\u2010Driven Extraction of Ginger Phytochemicals: Modeling, Optimization and Bioactivity Evaluation"],"prefix":"10.1111","volume":"91","author":[{"given":"Mohamed\u2010el\u2010Amine","family":"Ikhlef","sequence":"first","affiliation":[{"name":"Laboratory of Environmental Process Engineering, Faculty of Process Engineering University Constantine 3 Salah Boubnider  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouassila","family":"Larkeche","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Process Engineering, Faculty of Process Engineering University Constantine 3 Salah Boubnider  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"zermane","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Process Engineering, Faculty of Process Engineering University Constantine 3 Salah Boubnider  Constantine Algeria"},{"name":"Department of Chemical Engineering University Larbi Ben M'hidi Oum el Bouaghi  Oum el Bouaghi Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-8341","authenticated-orcid":false,"given":"Slimane","family":"Merouani","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Process Engineering, Faculty of Process Engineering University Constantine 3 Salah Boubnider  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2004.01.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36473"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604\u2010007\u20100777\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2019.1573829"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171011748"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0023\u20106438(95)80008\u20105"},{"key":"e_1_2_10_10_1","first-page":"13","article-title":"We Are IntechOpen, the World ' s Leading Publisher of Open Access Books Built by Scientists, for Scientists TOP 1 %","volume":"11","author":"Buckner C. 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