{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:12:35Z","timestamp":1789873955025,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130085"],"award-info":[{"award-number":["32130085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Zinc deficiency is a severe global public health problem. Traditional inorganic and organic zinc supplements have obvious drawbacks. Oysters are rich in zinc but suffer from insufficient deep processing and low economic value. Developing oyster peptide\u2013zinc complex (OPZ) is a feasible solution for both zinc supplementation and high\u2010value oyster utilization. This study optimized the chelation process of OPZ via single\u2010factor and response surface methods. The optimal parameters were confirmed as follows: chelation time 44\u00a0min, temperature 50\u00b0C, pH 6.95, liquid\u2010to\u2010solid ratio 1:4, peptide\u2010zinc ratio 1:1, with a chelation rate of 5.2498\u00a0mg\/g. Multispectral characterization verified OPZ formation. Amino acids residues \u2500NH\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      and \u2500COO\n                      <jats:sup>\u2212<\/jats:sup>\n                      participated in chelation, and the peptide chain structure rearranged. OPZ showed good acid stability and gastrointestinal digestion resistance in simulated physiological conditions. In zinc\u2010deficient mice, OPZ effectively restored body weight and food intake. It alleviated organ damage in liver, spleen, and small intestine. It also promoted zinc deposition in muscle, fur, serum, and femur to normal levels. OPZ had higher zinc bioavailability than zinc sulfate. This research clarifies OPZ's preparation and characterization. It provides technical support for oyster value\u2010added processing. It also lays a foundation for developing efficient third\u2010generation zinc supplements, with broad application prospects in functional foods and health products.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71167","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T10:09:41Z","timestamp":1780135781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural Elucidation and Zinc Supplement Potential of the High\u2010Bioavailability Oyster Peptide\u2013Zinc Complex"],"prefix":"10.1111","volume":"91","author":[{"given":"Ximing","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyao","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8008","authenticated-orcid":false,"given":"Shuzhen","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-8529","authenticated-orcid":false,"given":"Ming","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing &amp; Safety Control, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"National Engineering Research Center of Seafood, School of Food Science and Technology Dalian Polytechnic University  Dalian China"},{"name":"College of Food Science and Engineering Dalian Ocean University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2009\u201000117"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2022.100361"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61690\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.147835"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10062041"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13111652"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.08.017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.103649"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2025.118518"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA05248F"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2026.102188"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.146627"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2025.103147"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12588"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108927"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.12.4239"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.112035"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2026.101422"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010017\u20100309\u20104"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.10.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2025.103046"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.111796"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030762"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129043"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3FO60702J"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2025.106941"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2026.109415"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fufo.2024.100390"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3DT03579D"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2024.116945"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13325"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.103722"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107859"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.100985"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010020\u201000795\u20105"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.02.005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.138573"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10499\u2010023\u201001132\u20105"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.145077"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135468"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104188"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2026.119189"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129101"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods15020362"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.138288"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.114367"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.71167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:03:19Z","timestamp":1786075399000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.71167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/1750-3841.71167"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.71167","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71167"}}