{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:21:28Z","timestamp":1792441288935,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Lycopene use in water\u2010based foods is limited by poor dispersibility and low stability. Here, two food\u2010grade glyco\u2010carrier lycopene nanoformulations were prepared using dextran (lyc\u2010dextran) or\n                      <jats:sc>d<\/jats:sc>\n                      \u2010mannose (lyc\u2010mannose) and evaluated in vitro and in vivo. Both formed near\u2010spherical nanoparticles (190\u2013252\u00a0nm) with negative\n                      <jats:italic>\u03b6<\/jats:italic>\n                      \u2010potentials (\u2248\u221226 to \u221228\u00a0mV) and predominantly noncovalent assembly; encapsulation efficiencies were 70.0% and 68.8%, respectively. Under thermal\/photo stress (4\u201360\u00b0C; dark vs. 4000\u00a0lx), both nanoformulations increased lycopene retention; at 60\u00b0C\/4000\u00a0lx, 300\u2010min retention was 40.78% for free lycopene versus \u223c70%\u201372% (lyc\u2010dextran) and \u223c62%\u201367% (lyc\u2010mannose). The nanoformulations showed strong chemical antioxidant capacity and alleviated H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      \u2010induced oxidative injury in HUVECs (lower malondialdehyde [MDA], higher catalase [CAT]\/superoxide dismutase [SOD]\/glutathione peroxidase [GSH\u2010Px], with changes in Nrf2\/SIRT3\u2010related proteins). In\n                      <jats:sc>d<\/jats:sc>\n                      \u2010galactose\u2010treated mice, interventions were associated with reduced hepatic MDA, elevated antioxidant enzyme activities, a lower AST\/ALT ratio, and attenuated liver injury, accompanied by formulation\u2010associated shifts in gut microbiota structure. Overall, food\u2010grade glyco\u2010nanocarriers enhance lycopene stability and antioxidant\u2010related performance, supporting their potential for lycopene\u2010based nano\u2010functional foods.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71181","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:31:21Z","timestamp":1782207081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Strategy for Oxidative Damage: Lycopene Nanoformulations Improve Redox Homeostasis and Gut Microbiota Composition in Mice"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-6596","authenticated-orcid":false,"given":"Zhen","family":"Zuo","sequence":"first","affiliation":[{"name":"College of Life Sciences Xinjiang Normal University  Urumqi 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