{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:06:30Z","timestamp":1789387590029,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2023D01F34"],"award-info":[{"award-number":["2023D01F34"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Mulberry ripe fruit (MP) is a popular berry known for its rich content of health\u2010beneficial components such as anthocyanins and polysaccharides. While traditional Chinese medicine suggests therapeutic effects of mulberry fruits on diabetes, their high content of small\u2010molecule sugars discourages diabetic patients from consuming them. This study utilized\n                      <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                      CICC 24202 and\n                      <jats:italic>Lactobacillus brevis<\/jats:italic>\n                      YM 1301 to ferment mulberry homogenate at 37\u00b0C for 60\u00a0h. The fermented mulberry homogenate was freeze\u2010dried to obtain fermented mulberry product (FMP). The content of small\u2010molecular sugars in FMP decreased by approximately 50%, while the content of polysaccharides, the active components linked to the hypoglycemic effect of MP, increased by roughly 80%. The impact of FMP on type 2 diabetes (T2DM) was evaluated in a mouse model induced by a high\u2010fat diet combined with STZ. The findings revealed that FMP and MP improved various parameters, including fasting blood glucose, serum insulin, serum total cholesterol, triglycerides, and low\u2010density lipoprotein cholesterol, and FMP exerted a superior improving effect on these indices than MP. In addition, FMP also elevated levels of glucagon\u2010like peptide\u20101 (GLP\u20101) and adiponectin in serum, reduced epididymal fat accumulation, and alleviated renal function damage in diabetic mice. Therefore, lactic acid bacteria fermentation represents a promising strategy to reduce small\u2010molecular sugars in mulberry, enrich product diversity, and improve the health\u2010promoting properties of mulberry products.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71317","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:25:09Z","timestamp":1784874309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypoglycemic and Hypolipidemic Potentials of Mulberry Fermented With\n                    <i>Lactobacillus brevis<\/i>\n                    YM 1301 and\n                    <i>Lactobacillus plantarum<\/i>\n                    CICC 24202"],"prefix":"10.1111","volume":"91","author":[{"given":"Juan","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Medicine Aksu Vocational and Technical College  Aksu, Xinjiang Uyghur Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Science Shaanxi Normal University, Ministry of Education  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Science Shaanxi Normal University, Ministry of Education  Xi'an Shaanxi 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