{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:17:49Z","timestamp":1787980669826,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Diabetes mellitus is characterized by persistent hyperglycemia accompanied by dyslipidemia, oxidative stress, and progressive hepatic, renal, and hematological disturbances. This study evaluated the compositional, antioxidant, and preclinical antidiabetic potential of Trigonella foenum\u2010graecum (fenugreek) and Nigella sativa (black seed) powders, administered individually or combined, in alloxan\u2010induced diabetic rats. Fenugreek powder contained high crude fiber (22.1%) and moderate protein (20.5%), whereas black seed powder showed high crude fat (38.9%) and appreciable protein (20.9%). Total phenolic content was substantially higher in black seed powder (185.3\u00a0mg \u00b1 7.6\u00a0mg GAE\/g) than in fenugreek powder (47.1\u00a0mg \u00b1 2.0\u00a0mg GAE\/g), although both exhibited comparable DPPH radical scavenging activity (63.8%\u201363.9%). Diabetic rats received fenugreek, black seed, or their combination (100\u00a0mg\/kg body weight) for 28 days alongside healthy and untreated diabetic controls. All treatments improved glycemic status, with the combined treatment producing the greatest HbA1c reduction (8.9% to 5.1%) compared with fenugreek (6.4%), black seed (6.2%), and untreated diabetic rats (8.1%). Treatments also improved dyslipidemia, hematological indices, and hepatic and renal biomarkers, with the combined treatment consistently showing superior efficacy. These findings support fenugreek and black seed powders as bioactive\u2010rich functional ingredients with complementary glucose\u2010lowering and organ\u2010protective effects, highlighting their promise as a multi\u2010target dietary adjunct against diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>This study demonstrates that the combined use of Trigonella foenum\u2010graecum (fenugreek) and Nigella sativa (black seed) powders has potential as a functional food ingredient or nutraceutical formulation for dietary management of diabetes. Their complementary bioactive composition improved glycemic control, lipid metabolism, and liver and kidney function in a preclinical model, supporting their application in developing value\u2010added functional foods, health supplements, and plant\u2010based therapeutic diets aimed at reducing diabetes\u2010associated metabolic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71339","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:15:36Z","timestamp":1787195736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Supplementation With\n                    <i>Trigonella foenum\u2010graecum<\/i>\n                    and\n                    <i>Nigella sativa<\/i>\n                    Seed Powders Improves Glycemic Control, Dyslipidemia, and Organ Function in Alloxan\u2010Induced Diabetic Rats"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0504-6701","authenticated-orcid":false,"given":"Areeba","family":"Aslam","sequence":"first","affiliation":[{"name":"Faculty of Food and Home Sciences Muhammad Nawaz Shareef University of Agriculture Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Firdous","sequence":"additional","affiliation":[{"name":"Faculty of Food and Home Sciences Muhammad Nawaz Shareef University of Agriculture Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-6184","authenticated-orcid":false,"given":"Muhammad","family":"Waqar","sequence":"additional","affiliation":[{"name":"Food Technology and Innovation Research Center of Excellence School of Agricultural Technology and Food Industry Walailak University  Nakhon Si Thammarat Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliza","family":"Batool","sequence":"additional","affiliation":[{"name":"Faculty of Food and Home Sciences Muhammad Nawaz Shareef University of Agriculture Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-0349","authenticated-orcid":false,"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Faculty of Food and Home Sciences Muhammad Nawaz Shareef University of Agriculture Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-2858","authenticated-orcid":false,"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Zhengzhou Research Institute, Harbin Institute of Technology  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djilali","family":"Benabdelmoumene","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Animal Physiology, Department of Agronomic Sciences University Abdelhamid Ibn Badis  Mostaganem Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Science King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-6487","authenticated-orcid":false,"given":"Abdifetah Ibrahim","family":"Omar","sequence":"additional","affiliation":[{"name":"Jamhuriya Research Center Jamhuriya University of Science and Technology  Mogadishu Somalia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97545-8"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"99","article-title":"Antidiabetic Effects of Methanolic Extract of Trigonella foenumgraecum Seeds in Diabetic Rats","volume":"44","author":"Abduallah A. 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