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Rats (\n                      <jats:italic>n<\/jats:italic>\n                      = 30) were divided into six groups: a standard diet control and a hypercholesterolemic diet control (both on water) and four hypercholesterolemic diet treatment groups receiving whole or decaffeinated\n                      <jats:italic>C. arabica<\/jats:italic>\n                      or\n                      <jats:italic>C. canephora<\/jats:italic>\n                      beverages for 42 days (7.2 mL\/kg\/day). Lipid profile and oxidative stress biomarkers were determined in blood and liver samples. Decaffeination significantly altered the bioactive composition of the beverages, particularly the levels of chlorogenic acids, trigonelline, and diterpenes. No significant differences in the biological outcomes were observed among the four coffee\u2010treated groups. Therefore, based on pooled means across coffee\u2010treated groups, coffee consumption reduced non\u2010HDL cholesterol from 94.0 \u00b1 7.9 mg\/dL in the hyperlipidemic control group to 72.0 \u00b1 11.4 mg\/dL (23.5% reduction), triacylglycerol from 80.0 \u00b1 8.8 to 44.6 \u00b1 5.4 mg\/dL (44.3% reduction), hepatic lipid content from 10.8 \u00b1 0.8% to 8.1 \u00b1 0.8% (25.2% reduction), and hepatic lipid peroxidation markers from 85.7 \u00b1 7.7 to 28.0 \u00b1 4.6 nmol MDA\/mg protein (67.3% reduction). Overall, the hypolipidemic and antioxidant effects of coffee were independent of species and caffeine content. These findings provide insights into the impact of dichloromethane\u2010based decaffeination on the bioactive composition and biological effects of coffee beverages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>In a rat model of hyperlipidemia, decaffeinated coffee showed effects comparable to whole coffee on markers related to lipid metabolism and antioxidant protection. These findings may support the development and consumption of decaffeinated coffee products for individuals seeking to reduce caffeine intake.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71340","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:20:37Z","timestamp":1787311237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Coffee Decaffeination on Beverage Bioactives, Antioxidant Activity, and Lipid Metabolism in Hyperlipidemic Rats"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-066X","authenticated-orcid":false,"given":"Adriene Ribeiro","family":"Lima","sequence":"first","affiliation":[{"name":"Department of Bromatology Graduate Program in Applied Sciences to Health Products (PPG\u2010CAPS) Faculty of Pharmacy Fluminense Federal University (UFF) Niter\u00f3i Rio de Janeiro 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Andrade","family":"Abrah\u00e3o","sequence":"additional","affiliation":[{"name":"Bom Jesus do Itabapoana Campus Instituto Federal Fluminense (IFF)  Bom Jesus do Itabapoana Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eul\u00e1lia","family":"Mendes","sequence":"additional","affiliation":[{"name":"LAQV\u2013REQUIMTE, Faculty of Pharmacy University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Avelino Alves Andrade da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Faculty of Engineering University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Borges de Ara\u00fajo","family":"Paula","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis (DACT\/FCF) Federal University of Alfenas (UNIFAL\u2010MG) Alfenas Minas Gerais 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