{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:17:45Z","timestamp":1787980665446,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Post\u2010prandial glycemia is an important indicator of metabolic health and early glucose dysregulation. Mushroom\u2010derived \u03b2\u2010glucans have potential as functional ingredients for glycemic control, but their comparative efficacy and regulatory mechanisms remain unclear. In this study, \u03b2\u2010glucans from oyster mushroom (OMBG),\n                      <jats:italic>Ganoderma lucidum<\/jats:italic>\n                      (GBG), and\n                      <jats:italic>Hericium erinaceus<\/jats:italic>\n                      (HEBG) were evaluated using structural characterization, functional assays, simulated digestion, colonic fermentation, and in vivo experiments, with oat \u03b2\u2010glucan (OBG) included as a reference. OBG showed strong glucose diffusion\u2010retarding and enzyme\u2010inhibitory activities in vitro, whereas HEBG exhibited the best overall performance among mushroom\u2010derived \u03b2\u2010glucans, particularly in glucose adsorption, glucose diffusion retardation, and \u03b1\u2010glucosidase inhibition. During simulated gastrointestinal digestion, HEBG reduced starch hydrolysis and glucose release, and during colonic fermentation it supported microbial growth and carbohydrate utilization. In mice, HEBG improved oral glucose tolerance without affecting body weight, food intake, or organ indices. HEBG treatment was associated with reduced intestinal Sglt\u20101 expression, enhanced barrier\u2010related markers, including tight junction proteins and Muc2, and increased GLP\u20101 and PYY secretion. Multi\u2010omics analyses further indicated that HEBG altered gut microbiota composition, particularly enriching\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                      , and was associated with changes in serum metabolites related to carbohydrate and lipid metabolism. These findings suggest that HEBG may improve post\u2010prandial glucose homeostasis in association with a gut microbiota\u2013metabolite\u2013gut hormone network.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>HEBG may serve as a mushroom\u2010derived functional ingredient for post\u2010prandial glycemic management and could be incorporated into supplements, beverages, or starch\u2010based foods to help delay starch digestion and glucose release. Further studies should assess its processing stability and functional retention during food manufacturing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71341","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:46:47Z","timestamp":1786794407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Hericium erinaceus<\/i>\n                    \u03b2\u2010Glucan Improves Post\u2010Prandial Glycemic Homeostasis in Association With Changes in\n                    <i>Akkermansia muciniphila<\/i>\n                    , Serum Metabolites, and Gut Hormones"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-7043","authenticated-orcid":false,"given":"Zhineng","family":"Wang","sequence":"first","affiliation":[{"name":"College of Agriculture and Animal Husbandry Qinghai University  Xining 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