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Disruption of mitochondrial homeostasis impairs cellular energy metabolism and contributes to the overproduction of reactive oxygen species (ROS), leading to oxidative stress, chronic inflammation, and insulin resistance. These mitochondrial abnormalities exacerbate insulin resistance and impair pancreatic \u03b2\u2010cell function, thereby accelerating the progression of T2D. Emerging evidence highlights the therapeutic potential of plant\u2010derived biomolecules, particularly polyphenols found in traditional herbal teas, for mitigating oxidative stress and restoring mitochondrial integrity. This review explores the pathophysiological role of mitochondrial dysfunction and oxidative stress in T2D, with a focus on insulin action and \u03b2\u2010cell function. We review three South African herbal teas (Rooibos, Honeybush, and Bush tea) and summarize how, through regulation of the oxidoreductase enzyme system, upregulation of endogenous antioxidant enzymes, inhibition of pro\u2010oxidant enzymes, and support of mitochondrial biogenesis, demonstrating promising bioactivity. The review synthesizes current evidence on the herbal tea's key phytochemicals and their proposed mechanisms of action, highlighting their relevance in mitigating redox imbalance and preserving mitochondrial integrity within the context of diabetes. In addition, factors influencing their nutraceutical value, such as phytochemical composition, processing conditions, and bioavailability, are considered in relation to functional food development. By linking their antioxidant and anti\u2010inflammatory properties to mitochondrial protection, this review underscores their potential role as complementary interventions in the management of T2D. Although emerging in vitro and in vivo studies suggest promising bioactivity of the herbal teas, the current evidence base remains limited by a lack of well\u2010controlled human clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71351","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:57:11Z","timestamp":1786535831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["South African Herbal Teas and Diabetes\u2010Mediated Mitochondrial Dysfunction: Emerging Evidence and Mechanistic Insights"],"prefix":"10.1111","volume":"91","author":[{"given":"Shanika","family":"Reddy","sequence":"first","affiliation":[{"name":"Applied Microbial and Health Biotechnology Institute Cape Peninsula University of Technology  Bellville South 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