{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:55:30Z","timestamp":1790567730031,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Anthocyanins (ACNs) are natural bioactive compounds with promising anti\u2010colitis potential; however, their poor stability in the gastrointestinal tract limits effective colonic delivery. To address this challenge, this study developed a tannic acid (TA)\u2010based multilayer hydrogel delivery system incorporating ACN\u2010loaded microcapsules. In this system, TA participates in the formation of a mesoporous silica nanoparticles (MSN)\u2010associated TA\u2013Fe\n                      <jats:sup>3<\/jats:sup>\n                      <jats:sup>+<\/jats:sup>\n                      coordination network, which is subsequently embedded within a sodium alginate (SA)\/Ca\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sup>+<\/jats:sup>\n                      hydrogel matrix. ACNs were first loaded into MSN, followed by the deposition of a TA\u2013Fe\n                      <jats:sup>3<\/jats:sup>\n                      <jats:sup>+<\/jats:sup>\n                      coating to form microcapsules with an encapsulation efficiency of 87.20%. These microcapsules were subsequently embedded in an SA hydrogel to obtain the final formulation, designated AMTS (ACNs@MSN@TA\u2010Fe\n                      <jats:sup>3<\/jats:sup>\n                      <jats:sup>+<\/jats:sup>\n                      @SA).\u00a0In vitro simulated digestion showed that AMTS reduced the premature loss of ACNs during gastrointestinal transit and maintained a relatively stable detectable ACN fraction in the digestion medium, supporting the protective role of the carrier and its potential for subsequent delivery to the simulated colonic enzymatic phase.\n                    <\/jats:p>\n                    <jats:p>\u00a0In vivo\u00a0results showed that AMTS alleviated DSS\u2010induced colonic injury, reduced inflammatory responses, and enhanced intestinal barrier integrity. Compared with free ACNs, AMTS produced more pronounced improvements across several evaluated indices. Collectively, these findings indicate that AMTS represents a promising oral delivery platform to support the potential colonic delivery of ACNs and enhance their protective efficacy in the DSS\u2010induced colitis model, and may offer a practical strategy for the oral delivery of structurally labile natural bioactive compounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71369","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:44:55Z","timestamp":1788147895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tannic Acid\u2010Based Multilayers Anchoring Anthocyanin\u2010Loaded Mesoporous Silica Microcapsules: A Synergistic Hydrogel System for Ameliorating DSS\u2010Induced Colitis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6879-2089","authenticated-orcid":false,"given":"Dongji","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory of Coffee Quality and Safety of State Administration for Market Regulation, College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Coffee Quality and Safety of State Administration for Market Regulation, College of Food Science and Nutritional Engineering China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-8532","authenticated-orcid":false,"given":"Xiaoyun","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Coffee Quality and Safety of State Administration 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