{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:17:49Z","timestamp":1787980669727,"version":"build-2784847793"},"reference-count":129,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>With the growing interest in functional foods and their role in promoting health beyond basic nutrition, increasing attention has been directed toward the modulation of gut microbiota as a key determinant of human well\u2010being. In this context, prebiotics and probiotics have emerged as central bioactive ingredients due to their capacity to selectively influence microbial composition and metabolic activity in the gastrointestinal tract. Prebiotics are defined as nondigestible food components that are selectively utilized by beneficial microorganisms, leading to improved host health, whereas probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. This review explores the mechanisms of action, major sources, and documented health effects of both prebiotics and probiotics, with particular emphasis on their roles in digestive health, immune modulation, and the prevention or management of metabolic and inflammatory disorders. Special attention is given to xylooligosaccharides (XOS) as emerging prebiotics derived from lignocellulosic biomass, highlighting recent advances in enzymatic production processes using microbial enzymes, especially fungal xylanases. Furthermore, the paper discusses current biotechnological strategies for sustainable production, purification, and formulation of prebiotic and probiotic ingredients, as well as the growing evidence supporting their synergistic interaction when combined as synbiotics. Understanding the complex interplay between prebiotics, probiotics, and the gut microbiota is essential for the rational design of next\u2010generation functional foods and dietary interventions aimed at improving human health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71379","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:29:27Z","timestamp":1787650167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Xylooligosaccharides Production From Lignocellulosic Materials and Its Application as Prebiotics"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-2020","authenticated-orcid":false,"given":"Paula Cavion","family":"Costa","sequence":"first","affiliation":[{"name":"Enzymes and Biomasses Laboratory University of Caxias do Sul  Caxias do Sul Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marli","family":"Camassola","sequence":"additional","affiliation":[{"name":"Enzymes and Biomasses Laboratory University of Caxias do Sul  Caxias do Sul Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541\u20104337.2010.00135.x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.15376\/biores.18.1.1525\u20101544"},{"key":"e_1_2_14_4_1","unstructured":"Ahuja M.2021.Prebiotics Market Size by Ingredients (Fructo\u2010Oligosaccharide (FOS) Inulin Galacto\u2010Oligosaccharides (GOS) Mannan\u2010Oligosaccharide (MOS)) by Application (Prebiotic Food & Beverages Dairy Products Cereals Baked Food Fermented Meat Products Dry Food). Global Market Insights."},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FBP.2008.09.002"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.115631"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.15376\/biores.20.4.9886\u20109901"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARBPOL.2019.115460"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.080"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.17113\/ftb.53.04.15.4160"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12962"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2019.02.016"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002530100704"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c06279"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342079"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2019.122724"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOTECHADV.2016.09.001"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.INDCROP.2013.08.062"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010009\u20108892\u20105"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390903044768"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01765"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104\u201014282012005000024"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2012.11.021"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116022"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2011.10.083"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.731930"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2021.102190"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO00162H"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FM.2010.03.007"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713422"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010019\u201002973\u20108"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.HELIYON.2023.E18316"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3927(20000601)21:9<542::AID-MARC542>3.0.CO;2-7"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf401249g"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biombioe.2023.107038"},{"key":"e_1_2_14_36_1","volume-title":"Report of a Joint FAO\/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food","author":"FAO and WHO","year":"2002"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14050769"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2019.09.004"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01601"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60348b"},{"key":"e_1_2_14_41_1","unstructured":"Future Market Insights [FMI].2023.Future Market Insights [FMI]."},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.75"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1079\/nrr200479"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041037"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283\u00d713482996"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.04.006"},{"key":"e_1_2_14_47_1","unstructured":"Harmsen P. R.Bakker W.Huijgen andL.Bermudez.2010.Literature Review of Physical and Chemical Pretreatment Processes for Lignocellulosic Biomass. Wageningen UR Food & Biobased Research.https:\/\/www.researchgate.net\/publication\/254853217."},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2004.12.001"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cofs.2024.101238"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4222"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIORTECH.2023.128804"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70339"},{"key":"e_1_2_14_53_1","first-page":"131","article-title":"Xylooligosaccharides: An Economical Prebiotic From Agroresidues and Their Health Benefits","volume":"53","author":"Jain I.","year":"2015","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102891\u20109\u201058"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARBPOL.2024.123209"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.70320"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4ra02508c"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods7060092"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03170"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2018.03.111"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/6179375"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOTECHADV.2013.11.005"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1216674"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00017\u201008"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113225"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.791614"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2021.126290"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865\u2010016\u20100187\u20103"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5789232"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203717666160923155209"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.103831"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5gc01723h"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462\u20102920.13589"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2025.1655379"},{"key":"e_1_2_14_76_1","volume-title":"Avalia\u00e7\u00e3o da Extra\u00e7\u00e3o de hemicelulose e da Produ\u00e7\u00e3o de xilooligossacar\u00eddeos a Partir de um Subproduto de Eucalyptus oriundo de Uma Empresa de celulose","author":"Mafei T. D. T.","year":"2017"},{"key":"e_1_2_14_77_1","unstructured":"Majeed M. andR.Kamarei.2012.Bacillus coagulans: Probiotic of Choice.Sabinsa Europe."},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2009.0025"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.INDCROP.2010.04.005"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010017\u20108564\u20102"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9091021"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041107"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01047"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515003864"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2012.0035"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.124623"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.04.032"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1ra00449b"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2018.10.008"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.03.063"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2006.07.013"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PROCBIO.2006.05.011"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.54448\/IJN25212"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5fo00169b"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.02.047"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010012\u20100044\u2010x"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOTECHADV.2012.01.018"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113274"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263\u2010010\u20100206\u20106"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2020.01.005"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010005\u20101904\u20107"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106968.2002.tb11467.x"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BEJ.2022.108678"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIORTECH.2018.10.007"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00979"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FOODRES.2025.116461"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155\u20109600.1000461"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcdf.2014.12.003"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010019\u20100173\u20103"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARBPOL.2020.117118"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010arplant\u2010042809\u2010112315"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.17113\/ftb.61.04.23.8073"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal12111373"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2025.132919"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.15745"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO02688D"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068\u2010018\u20101262\u20101"},{"key":"e_1_2_14_118_1","volume-title":"Atividade Xilan\u00e1sica de Fungos Associados ao Trato Digestivo de Insetos: Potencial para Obten\u00e7\u00e3o de Xilooligossacar\u00eddeos a Partir de Farelo de Trigo","author":"Teixeira M. F. N.","year":"2023"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BITEB.2018.04.003"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12142681"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2022.127800"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106337"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA07140C"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068\u2010019\u20101423\u2010x"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00216"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FBIO.2025.107069"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819465-2.00004-8"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.70383"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109146"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.660266"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.71379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:23:29Z","timestamp":1787977409000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.71379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":129,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/1750-3841.71379"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.71379","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71379"}}