{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:26:26Z","timestamp":1793618786527,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Anthocyanins, as water\u2010soluble natural pigments, have garnered increasing interest in the field of natural products due to their significant biological activities. While existing studies have verified the hypoglycemic potential of\n                      <jats:italic>Lonicera caerulea<\/jats:italic>\n                      anthocyanins, few investigations simultaneously cover in vitro enzyme activity, in vivo hypoglycemic efficacy and the underlying regulatory mechanisms relevant to Type 2 diabetes. This research investigates the extraction conditions, and hypoglycemic effects in vitro and in vivo of\n                      <jats:italic>L. caerulea<\/jats:italic>\n                      anthocyanin\u2010rich extract (LCAE). The extract was prepared using ultrasound\u2010assisted acidified ethanol extraction followed by purification with macroporous adsorption resin. The maximum yield and purity of anthocyanin were 2.90 \u00b1 0.06 mg\/g and 22.10%, respectively. In vitro, LCAE effectively scavenged DPPH, ABTS\u02d9\n                      <jats:sup>+<\/jats:sup>\n                      , and \u02d9OH radicals in a concentration\u2010dependent manner, while also inhibiting \u03b1\u2010glucosidase activity with a maximum inhibition of 82.79%. In vivo, a C57BL\/6J mouse model of Type 2 diabetes mellitus (T2DM) was established using a high\u2010fat diet (HFD) combined with streptozotocin (STZ). LCAE significantly reduced fasting blood glucose (FBG) and glycated serum protein (GSP) levels. LCAE also improved the area under the curve (AUC) in the oral glucose tolerance test (OGTT), lowered HOMA\u2010IR, and enhanced insulin sensitivity, as evidenced by the quantitative insulin sensitivity check index (QUICKI). In addition, LCAE reduced serum levels of pro\u2010inflammatory cytokines (IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106), increased IL\u201010, enhanced hepatic antioxidant enzyme activities (CAT, SOD, GSH\u2010PX), and decreased MDA levels. Furthermore, LCAE ameliorated dyslipidemia in the liver and serum, alleviated hepatic steatosis, and pancreatic islet injury, downregulated hepatic\n                      <jats:italic>PEPCK<\/jats:italic>\n                      ,\n                      <jats:italic>G6Pase<\/jats:italic>\n                      ,\n                      <jats:italic>Pcx<\/jats:italic>\n                      gene expression, and upregulated AMPK expression. Overall, LCAE alleviated metabolic dysregulation in T2DM mice via multi\u2010target synergistic actions, providing experimental evidence for the potential development of LCAE as a natural functional hypoglycemic agent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>\n                      Blue honeysuckle (\n                      <jats:italic>Lonicera caerulea<\/jats:italic>\n                      L.) is a plant with both medicinal and food uses. Rich in bioactive compounds such as anthocyanins, it exhibits various biological activities, including antioxidant and hypoglycemic effects. Anthocyanin\u2010rich extracts derived from blue honeysuckle show promise as a natural ingredient for use in functional beverages or dietary supplements designed to help manage Type 2 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71387","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:16:41Z","timestamp":1791692201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extraction of Anthocyanin\u2010Rich Extract From\n                    <i>Lonicera caerulea<\/i>\n                    and Its Hypoglycemic Activity"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1711-8008","authenticated-orcid":false,"given":"Caihong","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro \u2010 Products Zhejiang Key Laboratory of Intelligent Food Logistic and Processing Key Laboratory of Post\u2010Harvest Handling of Fruits, Ministry of Agriculture and Rural Affairs, Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro \u2010 Products Zhejiang Key Laboratory of Intelligent Food Logistic and Processing Key Laboratory of Post\u2010Harvest Handling of Fruits, Ministry of Agriculture and Rural Affairs, Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro \u2010 Products Zhejiang Key Laboratory of Intelligent Food Logistic and Processing Key Laboratory of Post\u2010Harvest Handling of Fruits, Ministry of Agriculture and Rural Affairs, Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiling","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro \u2010 Products Zhejiang Key Laboratory of Intelligent Food Logistic and Processing Key Laboratory of Post\u2010Harvest Handling of Fruits, Ministry of Agriculture and Rural Affairs, Food Science Institute Zhejiang Academy of Agricultural Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiZhi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro \u2010 Products Zhejiang Key Laboratory of Intelligent Food Logistic and Processing Key Laboratory of Post\u2010Harvest Handling of Fruits, Ministry of Agriculture and Rural Affairs, Food Science Institute Zhejiang Academy of Agricultural 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