{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:18:15Z","timestamp":1787980695307,"version":"build-2784847793"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Species of\n                      <jats:italic>Diospyros<\/jats:italic>\n                      L. genus (Ebenaceae family) are known for their economic, nutritional, and pharmacological values. This study aimed to compare the neuroprotective effects of\n                      <jats:italic>Diospyros discolor<\/jats:italic>\n                      and\n                      <jats:italic>Diospyros ebenum<\/jats:italic>\n                      against dementia, with reference to their phytochemical composition. Chemical composition of both species was unveiled through ultra\u2010performance liquid chromatography\u2010electrospray tandem mass spectrometry (UPLC\u2013ESI\u2013MS\/MS). Promising fractions of both species were standardized against the major identified active constituent(s) via high\u2010performance liquid chromatography\u2013photodiode array detector (HPLC\u2013PDA). Both\n                      <jats:italic>Diospyros<\/jats:italic>\n                      species were evaluated for their neuroprotective activity in vivo using scopolamine\u2010induced dementia in animal model. UPLC\u2013ESI\u2013MS\/MS of the EtOAc fractions of\n                      <jats:italic>D. discolor<\/jats:italic>\n                      and\n                      <jats:italic>D. ebenum<\/jats:italic>\n                      resulted in identification of 14 and 48 compounds, respectively, which belong to different classes, namely, organic acids, phenolics, naphthoquinones, triterpenoids, and sterols. Gallic acid contents in EtOAc fractions of\n                      <jats:italic>D. discolor<\/jats:italic>\n                      and\n                      <jats:italic>D. ebenum<\/jats:italic>\n                      were 295.95 and 1.5\u00a0\u00b5g\/mg fraction, respectively. In elevated plus\u2010maze (EPM) test, a tendency towards reduction in the inflexion ratio (IR) was noticed in scopolamine\u2010injected group, however, groups treated with EtOAc fractions of\n                      <jats:italic>D. discolor<\/jats:italic>\n                      ,\n                      <jats:italic>D. ebenum<\/jats:italic>\n                      , and pure gallic acid displayed a counteraction pattern. In novel object recognition (NOR) test, tested groups showed the same discrimination index. In brain histological study, treated groups with\n                      <jats:italic>D. discolor<\/jats:italic>\n                      ,\n                      <jats:italic>D. ebenum<\/jats:italic>\n                      , and pure gallic acid revealed amelioration compared to scopolamine. In alignment, both EtOAc fractions and gallic acid counteracted the scopolamine\u2010induced dementia in rats and significantly lowered the levels of acetylcholinesterase. Thus,\n                      <jats:italic>Diospyros<\/jats:italic>\n                      species demonstrated a significant ameliorative effect on neurotoxicity induced by scopolamine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71397","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:22:38Z","timestamp":1787394158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Neuroprotective Effects of\n                    <i>Diospyros discolor<\/i>\n                    and\n                    <i>Diospyros ebenum<\/i>\n                    Leaf Bioactive Fractions In Vivo and Their UPLC\u2013ESI\u2013MS\/MS Chemical Characterization: A Comparative Study"],"prefix":"10.1111","volume":"91","author":[{"given":"Nada","family":"Fareed","sequence":"first","affiliation":[{"name":"Pharmacognosy Department Faculty of Pharmacy The British University in Egypt (BUE)  Cairo Egypt"},{"name":"Drug Research and Development Group (DRD\u2010G), Faculty of Pharmacy The British University in Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-2639","authenticated-orcid":false,"given":"Fadia S.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola M.","family":"Labib","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Tawfiq","sequence":"additional","affiliation":[{"name":"Drug Research and Development Group (DRD\u2010G), Faculty of Pharmacy The British University in Egypt  Cairo Egypt"},{"name":"Pharmacology Department, Faculty of Pharmacy The British University in Egypt (BUE)  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina M.","family":"El\u2010Kersh","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department Faculty of Pharmacy The British University in Egypt (BUE)  Cairo Egypt"},{"name":"Drug Research and Development Group (DRD\u2010G), Faculty of Pharmacy The British University in Egypt  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.011"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<112::AID-PTR488>3.0.CO;2-T"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.05.011"},{"key":"e_1_2_12_5_1","first-page":"287","article-title":"Pentacyclic Triterpenes in Euphorbia microsciadia With Their T\u2010cell Proliferation Activity","volume":"10","author":"Ayatollahi A. 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