{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:56:25Z","timestamp":1790567785384,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008641","name":"Chung Shan Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options.\n                      <jats:italic>Corchorus olitorius<\/jats:italic>\n                      L., a traditional edible plant widely consumed in Asia, possesses documented anti\u2010inflammatory properties; however, its anticancer potential remains unclear. This study investigated whether\n                      <jats:italic>Corchorus olitorius<\/jats:italic>\n                      L. leaf extract (COE) induces ferroptosis in KRAS\u2010mutant pancreatic cancer cells. The chemical composition of COE was characterized using high\u2010performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. A total of 11 compounds were identified, among which quercetin\u20103\u2010O\u2010glucoside was the most abundant. In our study, KRAS\n                      <jats:sup>G12D<\/jats:sup>\n                      \u2010mutant PANC1 cells exhibited greater resistance to ferroptosis than KRAS wild\u2010type BXPC3 cells. COE increased reactive oxygen species production and intracellular iron accumulation while suppressing antioxidant defenses, particularly in KRAS\u2010mutant PANC1 cells. Mechanistically, COE enhanced nuclear receptor coactivator 4\u2010mediated ferritinophagy and downregulated KRAS and glutathione peroxidase 4 expression. In PANC1 xenografts, oral administration of COE significantly inhibited tumor growth and increased iron accumulation within tumor tissues. Collectively, COE induces ferroptosis in KRAS\u2010mutant pancreatic cancer by disrupting redox homeostasis and activating ferritinophagy. These findings support the potential of COE as a dietary\u2010derived therapeutic strategy for KRAS\u2010driven PDAC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Corchorus olitorius<\/jats:italic>\n                      L. leaf extract (COE), a commonly consumed edible plant, may serve as a functional food with potential anticancer benefits, particularly for KRAS\u2010mutant pancreatic cancer. By promoting cancer cell death through disruption of oxidative balance and iron metabolism, COE may represent a promising food\u2010based therapeutic strategy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71410","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:28:19Z","timestamp":1787995699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary\u2010Derived\n                    <i>Corchorus olitorius<\/i>\n                    L. Extract Suppresses KRAS\u2010Mutant Pancreatic Cancer by Activating Ferritinophagy\u2010Dependent Ferroptosis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-7778","authenticated-orcid":false,"given":"Chiao\u2010Yun","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory and Biotechnology Chung Shan Medical University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charng\u2010Cherng","family":"Chyau","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology Hungkuang University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Rong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsuan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueching","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung City Taiwan"},{"name":"Department of Medical Research Chung Shan Medical University Hospital  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA07406K"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2022.102238"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.923915"},{"key":"e_1_2_9_5_1","unstructured":"Arter E.2025.Anti\u2010Cancerous and Anti\u2010Metastatic Effects ofCorchorus olitoriuson Breast Cancer Cell Lines.London Metropolitian 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