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In the present study, the PBG\u2010lowering potential of\n                      <jats:italic>U. cannabina<\/jats:italic>\n                      L. was confirmed both in vitro and in vivo, and its chemical constituents were preliminarily identified by UPLC\u2010triple\u2010TOF\u2010MS\/MS for the first time. Notably, acarbose (8\u00a0mg\/kg), a clinically approved first\u2010line\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010glucosidase inhibitor, and UCE20 (20% ethanol extract of\n                      <jats:italic>U. cannabina<\/jats:italic>\n                      L.) at 10\u00a0mg\/kg both significantly reduced PBG levels. Furthermore, UPLC\u2013triple\u2010TOF MS\/MS analysis combined with correlation analysis has preliminarily indicated that hydroxycinnamoyl quinates and flavonoid C\u2010glycosides may serve as the primary bioactive components responsible for the PBG\u2010lowering effect. These findings suggested\n                      <jats:italic>U. cannabina<\/jats:italic>\n                      L. holds potential as a medicinal ingredient or health food to assist in the regulation of PBG levels.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71417","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:10:58Z","timestamp":1788592258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postprandial Blood Glucose Lowering Effect of\n                    <i>Urtica cannabina<\/i>\n                    L. and Its Chemical Profiling via UPLC\u2013Triple\u2010TOF MS\/MS"],"prefix":"10.1111","volume":"91","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Yang","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingting","family":"Xu","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luya","family":"Wang","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Liu","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-3233","authenticated-orcid":false,"given":"Huilan","family":"Yue","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology  Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"181","article-title":"Antidiabetic Effect of Hydroalcholic Urtica dioica Leaf Extract in Male Rats With Fructose\u2010Induced Insulin Resistance","volume":"37","author":"Ahangarpour A.","year":"2012","journal-title":"Iranian Journal of Medical Sciences"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387\u2010021\u201000152\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27248872"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09717"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367\u2010326X(03)00182\u20105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.19.2090"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.062"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.31621"},{"key":"e_1_2_9_11_1","first-page":"224","article-title":"Diabetes Mellitus: A Review","volume":"3","author":"Deshmukh C. 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