{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:56:47Z","timestamp":1790567807273,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study focuses on the resource utilization of\n                      <jats:italic>Ficus pumila<\/jats:italic>\n                      Linn. (FPL) by valorizing its often\u2010discarded hulls, aiming to reduce waste and enhance material value. An ultrasonic\u2010assisted deep eutectic solvent (DES) extraction method was optimized using response surface methodology to obtain polysaccharides (FPLP). The optimal DES system was choline chloride:oxalic acid at a molar ratio of 1.5:1, DES water content of 54%, ultrasonication time of 55\u00a0min, extraction temperature of 69\u00b0C, liquid\u2010to\u2010solid ratio of 21:1\u00a0mL\/g, and ultrasonic power of 240\u00a0W. Under these conditions, the extraction yield of FPLP reached 0.9524%. This yield was 4.44\u2010 and 1.45\u2010fold higher than those achieved by conventional hot\u2010water and ultrasonic\u2010water extraction, respectively. The crude FPLP was further purified by DEAE and Sephadex G\u201075 chromatography to obtain a refined polysaccharide, FPLP\u20101. Bioactivity evaluations demonstrated that FPLP\u20101 exhibits in vitro antioxidant activity (ABTS\u00b7\n                      <jats:sup>+<\/jats:sup>\n                      scavenging IC\n                      <jats:sub>50<\/jats:sub>\n                      = 2.587\u00a0mg\/mL) and hypoglycemic potential (\u03b1\u2010amylase inhibition IC\n                      <jats:sub>50<\/jats:sub>\n                      = 1.560\u00a0mg\/mL). Moreover, FPLP\u20101 showed potent in vivo antioxidant effects by protecting zebrafish keratinocytes from metronidazole\u2010induced apoptosis, along with broad in vitro immunomodulatory functions, including promoting splenocyte proliferation, enhancing macrophage phagocytosis, and stimulating the secretion of NO, TNF\u2010\u03b1, and IL\u20106 in a concentration\u2010dependent manner. These findings highlight the promising potential of FPLP\u20101 as a multifunctional bioactive compound.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71429","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:25:20Z","timestamp":1788859520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of Ultrasound\u2010Assisted Deep Eutectic Solvent Extraction, Characterization, and Antioxidant, Hypoglycemic, and Immunoregulatory Activities of Polysaccharide from the\n                    <i>Ficus pumila<\/i>\n                    Linn."],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-2156","authenticated-orcid":false,"given":"Yao","family":"Wen","sequence":"first","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University  Guangzhou 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