{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:56:47Z","timestamp":1790567807724,"version":"4.1.0"},"reference-count":102,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32502417"],"award-info":[{"award-number":["32502417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M742606"],"award-info":[{"award-number":["2023M742606"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Water\u2010soluble oyster mushroom polysaccharides (OMPs) are multifunctional biopolymers with growing relevance in food and health\u2010related applications. This review summarizes recent progress in the extraction, purification, structural features, biological activities, and food applications of OMPs, with particular emphasis on tentative structure\u2013activity relationships constrained by heterogeneous experimental evidence. Conventional and emerging extraction approaches, including hot water, enzyme\u2010assisted, ultrasound\u2010assisted, and microwave\u2010assisted methods, are compared in terms of yield and structural integrity. The monosaccharide profiles of OMP fractions vary considerably across different preparation conditions: glucose is universally the dominant component (17.78%\u2013100%), followed by mannose (3.60%\u201340.34%) and galactose (3.09%\u2013100%), with this compositional variation largely driven by extraction approaches, purification procedures, and fractionation strategies. Water\u2010soluble OMPs are mainly \u03b2\u2010glucans with \u03b2\u2010(1\u21923)(1\u21926)\u2010linked glucose backbones, while small amounts of galactans occur in certain fractions. A wide range of in vitro and animal assays report antioxidant, antitumor, anti\u2010obesity, immunoregulatory, and gastrointestinal protective capacities of OMPs, yet these biological outcomes are dependent on OMP purity, molecular weight range, experimental dosage, and cell\/animal model systems. Substantial in vitro and in vivo evidence confirms that OMP bioactive potency closely correlates with monosaccharide composition, molecular weight profile, and functional group distribution. Chemical modifications (e.g., sulfation, phosphorylation, selenization) can further boost OMP bioactivities. In food systems, \u03b2\u2010(1\u21923)\/(1\u21926)\u2010glucan\u2010rich OMPs have been used as stabilizers and texture modifiers. Despite progress, challenges remain in large\u2010scale production, structural standardization, and mechanistic elucidation. Future studies should integrate advanced analytical techniques, multiomics strategies, and artificial intelligence (AI)\u2010assisted modeling to facilitate rational design and industrial application of OMP\u2010based functional materials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71446","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:03:01Z","timestamp":1789034581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation, Structural Features, Bioactivities, and Food Application of Oyster Mushroom Polysaccharides: A Review"],"prefix":"10.1111","volume":"91","author":[{"given":"Wei","family":"Tang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin China"},{"name":"Zhejiang Kangrun Pharmaceutical Co., Ltd  Huzhou China"},{"name":"College of Food Science and Technology Whole Grain Nutritious Food Processing Technology Research and Experimental Base of Ministry of Agriculture and Rural Affairs Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiteng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Alaer Sunond Airy Co., Ltd  Alaer China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyu","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Whole Grain Nutritious Food Processing Technology Research and Experimental Base of Ministry of Agriculture and Rural Affairs Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanwu","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Kangrun Pharmaceutical Co., Ltd  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Tang","sequence":"additional","affiliation":[{"name":"Zhejiang Kangrun Pharmaceutical Co., Ltd  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7540-1038","authenticated-orcid":false,"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biology and Environmental Engineering Zhejiang Shuren University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9206-3715","authenticated-orcid":false,"given":"Hao","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Whole Grain Nutritious Food Processing Technology Research and Experimental Base of Ministry of Agriculture and Rural Affairs Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-7365","authenticated-orcid":false,"given":"Xiaoyin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Management Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co\u2010construction by Ministry and Province), School of Food Science and Technology Shihezi University  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tarim University  Alar China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2016.1210162"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5897\/ajb2014.14249"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2016.11.043"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00619\u201017"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1051\/e3sconf\/202021501001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0008\u20106215(03)00240\u20104"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127173"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0144\u20108617(95)00076\u20103"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3648"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.33263\/briac112.89158930"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.26599\/fmh.2025.9420046"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.01.164"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140236"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.107"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010019\u20101982\u20103"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2016.4594"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.26599\/fmh.2025.9420038"},{"key":"e_1_2_12_19_1","unstructured":"Global Biodiversity Information Facility.2026. \u201cPleurotusostreatus(Jacq.) P. Kumm.\u201dGBIF Backbone Taxonomy. Accessed January 6.https:\/\/www.gbif.org\/species\/2526530."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2020.108037"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3fo00089c"},{"key":"e_1_2_12_22_1","first-page":"43","article-title":"Oyster Mushroom: A Rich Source of Antioxidants","volume":"1","author":"Gupta K. K.","year":"2017","journal-title":"Incredible World of Biotechnology"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1243\/09544119JEIM613"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00658"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2021.106952"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13794"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5fo00678c"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102891\u201010\u201052"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2024.07.020"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.26599\/fmh.2025.9420067"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11030417"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2014.05.045"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2185-3_1"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.12.007"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8050129"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136097"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11557\u2010016\u20101266\u20109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.01.129"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c00745"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127470"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.01.040"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.143453"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.152"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2010.10.026"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145261"},{"key":"e_1_2_12_46_1","first-page":"242","volume-title":"McGraw\u2010Hill Yearbook of Science & Technology 1999","author":"Martinez\u2010Carrera D.","year":"1998"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.05.102"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400897"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2020.105021"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2012.06.016"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2010.07.036"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.917"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2025.104046"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12234347"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2015.10.016"},{"key":"e_1_2_12_56_1","first-page":"21","article-title":"Oyster Mushroom: Cultivation, Bioactive Significance and Commercial Status","volume":"2","author":"Rathod M. G.","year":"2021","journal-title":"Frontiers in Life Science"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2021.105412"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/1377\/1\/012064"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.113895"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/f11101055"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1111955"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2022.105516"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2008.06.036"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2024.11.006"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.17221\/1361\u2010cjfs"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2024.110763"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2024.11.010"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/app15031655"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2015.04.013"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28196975"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2008.09.004"},{"issue":"159","key":"e_1_2_12_72_1","first-page":"54960","article-title":"Substances Generally Recognized as Safe","volume":"18","author":"US Food and Drug Administration","year":"2016","journal-title":"Federal Register"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.12.034"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.09.002"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27082591"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.10.049"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.174"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.112146"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13060891"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765201720150635"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2010.04.008"},{"key":"e_1_2_12_82_1","first-page":"5","volume-title":"Advances in Ultrasound Technology for Environmental Remediation","author":"Wu T. Y.","year":"2012"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2024.01.007"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.490"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf300423z"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.11.079"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2008.12.015"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2012.03.020"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2025.120797"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.26599\/fmh.2025.9420042"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.glycos.2025.100010"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.26599\/FMH.2025.9420045"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010015\u20100964\u20101"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.11.194"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.08.008"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf2824"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.10.168"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.101"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.12.070"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040269"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134318"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.03.043"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.09.076"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.71446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:25:08Z","timestamp":1790565908000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.71446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":102,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/1750-3841.71446"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.71446","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71446"}}