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Propolis is a bee\u2010derived natural product rich in bioactive compounds and widely recognized for its antioxidant, anti\u2010inflammatory, and immunomodulatory properties. This study evaluated the effects of Brazilian green propolis, a hydroalcoholic green propolis extract, and a residue\u2010derived extract obtained from the essential oil extraction process on high\u2010fat diet\u2013induced MASLD in male C57BL\/6 mice. Animals were allocated into five groups: control diet (10% fat), high\u2010fat (HF) diet (50% fat), HF supplemented with green propolis (HFGP, 2%), HF supplemented with green propolis extract (HFGPE, 2%), and HF supplemented with green propolis residue (HFGPR, 2%) for 12 weeks. Chemical analysis identified artepillin C as a major constituent in both extracts. Supplementation with Brazilian green propolis and its derivatives significantly reduced body weight gain, improved lipid profile and glycemic control, and exerted marked antioxidant effects. In addition, propolis supplementation downregulated the expression of key lipogenic genes and promoted a pronounced anti\u2010inflammatory response, resulting in a significant attenuation of hepatic steatosis. Collectively, these findings indicate that Brazilian green propolis effectively mitigates obesity\u2010induced metabolic disturbances and tissue damage. Notably, residue\u2010derived extracts from the essential oil extraction process represent a sustainable, cost\u2010effective, and promising therapeutic strategy for obesity and its associated metabolic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71470","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:33:06Z","timestamp":1789551186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brazilian Green Propolis and Essential Oil Residues Improve Metabolic Dysfunction by Modulating Key Hepatic Lipogenic Genes in High\u2010Fat Diet\u2010Fed Mice"],"prefix":"10.1111","volume":"91","author":[{"given":"Caroline Alves de","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Biology Rio de Janeiro State University  Rio de Janeiro 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