{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:33:28Z","timestamp":1793082808293,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Quince (\n                      <jats:italic>Cydonia oblonga<\/jats:italic>\n                      Mill.) leaves are an abundant yet underutilized agricultural by\u2010product that is rich in phenolic compounds and therefore represents a promising feedstock for value\u2010added bioactive extracts. This study optimized the green ultrasound\u2010assisted extraction (UAE) of bioactive compounds from quince leaves using a sequential statistical approach based on Plackett\u2013Burman screening and Taguchi\u2010based criteria importance through intercriteria correlation (CRITIC)\u2010weighted grey relational analysis (GRA). Under the optimum conditions (solid\u2010to\u2010liquid ratio 3:50\u00a0g\/mL, 50% (v\/v) ethanol, and 75\u00b0C), the extract exhibited a total phenolic content (TPC) of 9210.44 \u00b1 138.25\u00a0mg GAE L\n                      <jats:sup>\u2212<\/jats:sup>\n                      <jats:sup>1<\/jats:sup>\n                      , a total flavonoid content (TFC) of 6180.67 \u00b1 94.25\u00a0mg CE L\n                      <jats:sup>\u2212<\/jats:sup>\n                      <jats:sup>1<\/jats:sup>\n                      and a DPPH free radical\u2010scavenging capacity of 76.53 \u00b1 3.65\u00a0mmol TE L\n                      <jats:sup>\u2212<\/jats:sup>\n                      <jats:sup>1<\/jats:sup>\n                      . Triplicate confirmation experiments validated the model, with an overall prediction accuracy of 97.69%. Ethanol concentration exerted the greatest influence on the grey relational grade (36.28%). Under identical operating conditions, the optimized UAE provided the most balanced extraction performance. It yielded the highest TPC, antioxidant activity, anti\u2010inflammatory activity, and \u03b1\u2010amylase inhibition relative to maceration, magnetic stirring, hand\u2010shaking, and reflux, while LC\u2013MS\/MS identified quinic and chlorogenic acids as the principal constituents. These results indicate that the UAE optimized through a Taguchi\u2010based CRITIC\u2010weighted GRA is an effective and sustainable strategy for producing bioactive\u2010rich extracts from quince\u2010leaf waste.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical Applications<\/jats:title>\n                    <jats:p>\n                      This study provides a practical, statistically grounded route for converting quince (\n                      <jats:italic>Cydonia oblonga<\/jats:italic>\n                      Mill.) leaf waste, an abundant agro\u2010industrial by\u2010product, into phenolic\u2010rich extracts using a green, food\u2010grade ultrasound\u2010assisted process. The sequential screening and multi\u2010response optimization framework can be adopted by food, nutraceutical, and functional\u2010ingredient manufacturers to maximize antioxidant, anti\u2010inflammatory, and enzyme\u2010inhibitory activities while minimizing solvent and energy use, supporting cost\u2010effective and sustainable valorization of leaf biomass.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71517","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:36:45Z","timestamp":1790678205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Ultrasound\u2010Assisted Extraction of Bioactive Phenolics From Quince (Cydonia oblonga) Leaves: Multi\u2010Response Optimization, LC\u2013MS\/MS Profiling, and Comparison With Conventional Methods"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-0496","authenticated-orcid":false,"given":"Mehmet","family":"G\u00fcldane","sequence":"first","affiliation":[{"name":"Chemistry and Chemical Processing Technology Department, Pamukova Vocational School Sakarya University of Applied Sciences  Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Food Processing Department, Pamukova Vocational School Sakarya University of Applied Sciences  Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumeysa","family":"\u015eekero\u011flu","sequence":"additional","affiliation":[{"name":"Food Processing Department, Pamukova Vocational School Sakarya University of Applied Sciences  Sakarya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00405000.2025.2499196"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.137846"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2025.103557"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010025\u201001781\u20103"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14783363.2024.2331758"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA05914C"},{"key":"e_1_2_10_8_1","first-page":"145","article-title":"In\u2010Vitro Evaluation of the Anti\u2010inflammatory Potential of Selected Jamaican Plant Extracts Using the Bovine Serum Albumin Protein Denaturation Assay","volume":"47","author":"Bailey\u2010Shaw Y. 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