{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:26:36Z","timestamp":1793618796007,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Brain injury induced by hypobaric hypoxia is a concern for individuals exposed to high\u2010altitude environments. This study evaluated the protective potential of prophylactic selenium\u2010enriched\n                      <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic>\n                      (SeLRS) administration in C57BL\/6 mice exposed to hypobaric hypoxia. Results showed that just 1 day of hypoxic exposure induced significant anxiety\u2010like, depressive\u2010like, and cognitive impairments, accompanied by hippocampal\u2010amygdala structural damage, a decreased glutamate\/gamma\u2010aminobutyric acid ratio, and elevated oxidative stress and neuroinflammation. Critically, injury related abnormalities were still evident after 7 days of exposure, indicating that hypobaric hypoxia\u2010associated brain injury was sustained under prolonged exposure conditions. Oral administration of SeLRS significantly improved behavioral and cognitive deficits, reduced neuroinflammation, attenuated hippocampal\u2010amygdala damage. SeLRS administration was also associated with altered whole\u2010brain glutamate content and amelioration of gut microbiota dysbiosis. 16S rRNA sequencing showed changes in the relative abundances of several taxa, including\n                      <jats:italic>Muribaculum<\/jats:italic>\n                      ,\n                      <jats:italic>Clostridium<\/jats:italic>\n                      ,\n                      <jats:italic>Prevotella<\/jats:italic>\n                      , and\n                      <jats:italic>Akkermansia<\/jats:italic>\n                      , which have previously been linked to neurotransmitter\u2010related metabolic pathways. Overall, these findings support the potential of the complete SeLRS preparation as a probiotic\u2010based nutritional strategy for mitigating hypobaric hypoxia\u2010associated brain injury.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71521","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:12:38Z","timestamp":1791691958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selenium\u2010Enriched\n                    <i>Lacticaseibacillus rhamnosus<\/i>\n                    Alleviates Hypobaric Hypoxia\u2010Induced Brain Injury via Regulation of Gut Microbiota and Neurotransmitter Homeostasis"],"prefix":"10.1111","volume":"91","author":[{"given":"Yinghui","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Gai","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-4657","authenticated-orcid":false,"given":"Dongyan","family":"Shao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-1792","authenticated-orcid":false,"given":"Junling","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences and Technology Northwestern Polytechnical University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169\u2010328X(94)00217\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2017.12.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101343"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201031730\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v15.i6.104809"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1705487"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201030717\u20108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2015.01.036"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010024\u201010097\u20104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010022\u201001226\u20103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010022\u201003513\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00037"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010019\u20100540\u20104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568\u2010025\u201001898\u20102"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1679858"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.17992\/lbl.2019.11.257"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010019\u20100227\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155529"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2024.741603"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201028165\u20103"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.01121\u201023"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00355a021"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00145"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1501999"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.634069"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107182"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1487953"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001743\u20101"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000041479"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2023.05.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0096\u20102016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13081849"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010024\u201003133\u20101"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15060643"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181d3cdbe"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20100327(95)00025\u2010I"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2013.1014"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113246"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.02.021"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2019.1586039"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.11.037"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14020160"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115034"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010021\u201000796\u20103"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41538\u2010025\u201000589\u20103"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220076"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12030359"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201080425\u20108"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1019103"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2016.10.011"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123\u2010200208000\u201000003"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3409679"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4163188"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.907239"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16162660"}],"container-title":["Journal of Food Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1750-3841.71521","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1750-3841.71521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:38:14Z","timestamp":1793615894000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1750-3841.71521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/1750-3841.71521"],"URL":"https:\/\/doi.org\/10.1111\/1750-3841.71521","archive":["Portico"],"relation":{},"ISSN":["0022-1147","1750-3841"],"issn-type":[{"value":"0022-1147","type":"print"},{"value":"1750-3841","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71521"}}