{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:46:38Z","timestamp":1791693998669,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study investigated the prebiotic properties of the supernatant from gluconic acid\u2010hydrolyzed alkali\u2010soluble\n                      <jats:italic>Poria cocos<\/jats:italic>\n                      polysaccharide (s\u2010GA\u2010PCP). s\u2010GA\u2010PCP directly promoted the proliferation of\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      strains. Among the s\u2010GA\u2010PCP\u2010utilizing strains, strain L10 (\n                      <jats:italic>Bifidobacterium pseudolongum<\/jats:italic>\n                      ) exhibited the broadest feeding capability, as its fermentation broth supported the growth of all six non\u2010utilizing strains. Analyses revealed that L10 produced a more diverse oligosaccharide profile and accumulated higher levels of amino acid and peptide metabolites. Furthermore, all tested primary broths reduced ROS, with strain\u2010specific effects on antioxidant enzymes in HepG2 cells. The broths from strains L10, LQ\u2010GL, and L1 showed the most pronounced effects, significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) increasing superoxide dismutase (SOD), glutathione peroxidase (GSH\u2010Px), and catalase (CAT) activities while decreasing malondialdehyde (MDA) content. Secondary fermentation with non\u2010utilizing strains resulted in strain\u2010pair\u2010specific modulation of ROS scavenging capacity. Collectively, these findings indicate that s\u2010GA\u2010PCP exerts prebiotic effects through strain\u2010specific feeding and that its functional outcomes not only depend on primary fermentation but are also dynamically regulated by sequential microbial metabolism. This study provides a scientific basis for screening and applying sequential fermentation strain combinations of\n                      <jats:italic>P. cocos<\/jats:italic>\n                      polysaccharides, thereby supporting precision prebiotic design.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1750-3841.71567","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:09:45Z","timestamp":1791691785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feeding Effect and Antioxidant Capacity of Fermentation Broths Based on Strain\u2010Specific Utilization of\n                    <i>Poria cocos<\/i>\n                    Polysaccharide 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