{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:08:35Z","timestamp":1776802115191,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Objective<\/jats:title>To evaluate the diagnostic utility of interferon\u2010\u03b3 release assay (T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content>) for the differential diagnosis between C<\/jats:styled-content>rohn's disease (CD<\/jats:styled-content>) and intestinal tuberculosis (ITB<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 103 CD<\/jats:styled-content> and 88 ITB<\/jats:styled-content> patients, confirmed by histology and anti\u2010tuberculosis treatment response from 2003 to 2011, were included. Their characteristics and clinical features were recorded. M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> (MTB) polymerase chain reaction (PCR<\/jats:styled-content>) of IS6110, in vitro<\/jats:italic> T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content>, tuberculin skin test (TST<\/jats:styled-content>), immunoglobulin G (IgG<\/jats:styled-content>) antibody to MTB<\/jats:styled-content> (protein chip), serum anti\u2010S<\/jats:styled-content>accharomyces cerevisiae<\/jats:italic> antibodies (ASCA IgG<\/jats:styled-content>, chronic inflammatory bowel disease profile) and acid\u2010fast staining of biopsied colonic tissue specimens were performed. Statistical analysis was conducted to determine their concordance with the diagnosis and its sensitivity, specificity, positive (PPV<\/jats:styled-content>) and negative predictive value (NPV<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Abnormal pulmonary X<\/jats:styled-content>\u2010ray, ascites and lesions of both cecum and ascending colon were more associated with ITB<\/jats:styled-content>, while intestinal surgery and lesions of both ileum and adjacent colon were more commonly seen in CD<\/jats:styled-content>. Significant diagnostic concordance was found using T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> (\u03ba\u2009=\u20090.786) by consistency test. The sensitivity, specificity, PPV<\/jats:styled-content> and NPV<\/jats:styled-content> of T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> were 86%, 93%, 88% and 91%, respectively, and the sensitivity and NPV<\/jats:styled-content> were significantly higher than other examinations (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>T\u2010SPOT<\/jats:styled-content>.TB<\/jats:styled-content> is a valuable assay in differentiating ITB<\/jats:styled-content> from CD<\/jats:styled-content>, particularly in the diagnostic exclusion of ITB<\/jats:styled-content> based on its high specificity and NPV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12017","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T15:22:14Z","timestamp":1353684134000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Utility of in vitro<\/i> interferon\u2010\u03b3 release assay in differential diagnosis between intestinal tuberculosis and C<\/scp>rohn's disease"],"prefix":"10.1111","volume":"14","author":[{"given":"Yuan","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital Wuhan University School of Medicine Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng Ming","family":"Yi","sequence":"additional","affiliation":[{"name":"Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi Vishal","family":"Luckheeram","sequence":"additional","affiliation":[{"name":"Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Huang","sequence":"additional","affiliation":[{"name":"Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital Wuhan University School of Medicine Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital Wuhan University School of Medicine Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital Wuhan University School of Medicine Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhongnan Hospital Wuhan University School of Medicine Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital Wuhan University School of Medicine Wuhan Hubei Province China"},{"name":"Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases Wuhan Hubei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.3.295"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization.Global tuberculosis control: WHO report 2011. 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