{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T09:27:23Z","timestamp":1744363643766},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Objective<\/jats:title>This study was aimed to assess whether the efficacy of one\u2010week triple therapy comprising of proton pump inhibitor, amoxicillin and clarithromycin (PPI\/A\/C) on Helicobacter pylori<\/jats:italic> (H. pylori<\/jats:italic>) infection in S<\/jats:styled-content>ingapore has decreased over the duration from 2005 to 2010.<\/jats:p><\/jats:sec>Methods<\/jats:title>The clinical data of H<\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010positive patients treated with one\u2010week PPI\/A\/C<\/jats:styled-content> in 2005 and 2010 were reviewed retrospectively using a registry database. The primary endpoint was the difference in treatment success rate.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 465 patients (n<\/jats:italic>\u2009=\u2009174 in 2005 and n<\/jats:italic>\u2009=\u2009291 in 2010) were analyzed. In 2010, compared with 2005, the mean age of patients was younger (47 vs<\/jats:italic> 56 years, P<\/jats:italic>\u2009<\u20090.001) and the proportion of foreigners was higher (19.9% vs<\/jats:italic> 5.7%, P<\/jats:italic>\u2009<\u20090.001). The success rate of H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication remained similar over the two time periods (90.2% in 2005 vs<\/jats:italic> 88.7% in 2010, P<\/jats:italic>\u2009=\u20090.597). Multinomial logistic regression revealed that mean age, gender, diagnosis and nationality had no impact on the success of H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>From 2005 to 2010, there was no significant decrease in the efficacy of one\u2010week PPI<\/jats:styled-content>\/A\/C<\/jats:styled-content> for the treatment of H<\/jats:styled-content>.\u2009pylori<\/jats:italic> infection. This treatment regime remained an effective first\u2010line therapy for H<\/jats:styled-content>.\u2009pylori<\/jats:italic> infection in S<\/jats:styled-content>ingapore.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12024","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T17:26:39Z","timestamp":1355851599000},"page":"100-104","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Is there still a role for empiric first\u2010line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for H<\/scp>elicobacter pylori<\/i> infection in S<\/scp>ingapore? Results of a time trend analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"Tiing Leong","family":"Ang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luokai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Chiam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwong Ming","family":"Fock","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng Kiong","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06188.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05314.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00691.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.210"},{"issue":"1","key":"e_1_2_5_8_1","first-page":"A530","article-title":"Significance of antibiotic resistant Helicobacter pylori in a Chinese population","volume":"134","author":"Fock KM","year":"2008","journal-title":"Gastroenterology"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.03.391"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_5_11_1","first-page":"409","article-title":"Worldwide H. pylori antibiotic resistance: a systematic review","volume":"19","author":"De Francesco V","year":"2010","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03386.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00788.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i40.5118"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00740-07"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4843-4847.2004"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03174.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00841.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3031"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(03)00131-9"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:29:03Z","timestamp":1697452143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/1751-2980.12024"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12024","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]},"assertion":[{"value":"2013-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}