{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:08:54Z","timestamp":1755925734826},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (<jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content>) screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gastric juice was collected from 101 participants who underwent endoscopy in the <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>utpatient <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ndoscopy <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eking <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hird <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital. The participants were divided into three groups: the normal mucosa or chronic non\u2010atrophic gastritis (<jats:styled-content style=\"fixed-case\">NM\u2010CNAG<\/jats:styled-content>) group (<jats:italic>n<\/jats:italic>\u2009=\u200935), advanced gastric cancer (<jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content>) group (<jats:italic>n<\/jats:italic>\u2009=\u200933) and <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content> group (<jats:italic>n<\/jats:italic>\u2009=\u200933). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak (<jats:styled-content style=\"fixed-case\">P<jats:sub>1<\/jats:sub>FI<\/jats:styled-content>) was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean fluorescence intensity of <jats:styled-content style=\"fixed-case\">P<jats:sub>1<\/jats:sub>FI<\/jats:styled-content> of gastric juice in <jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content> (92.1\u2009\u00b1\u200910.7) and <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content> (90.8\u2009\u00b1\u200912.0) groups was significantly higher than that in the <jats:styled-content style=\"fixed-case\">NM\u2010CNAG<\/jats:styled-content> group (55.7\u2009\u00b1\u20097.5) (<jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content>\u2005<jats:italic>vs<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">NM\u2010CNAG<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.006 and <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content>\u2005<jats:italic>vs<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">NM\u2010CNAG<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.015, respectively). The areas under the receiver operating characteristic curves for the detection of <jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content> were 0.681 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.553\u20130.810, <jats:italic>P<\/jats:italic>\u2009=\u20090.010) and 0.655 (95% CI 0.522\u20130.787, <jats:italic>P<\/jats:italic>\u2009=\u20090.028). With the <jats:styled-content style=\"fixed-case\">P<jats:sub>1<\/jats:sub>FI<\/jats:styled-content> of \u226547.7, the sensitivity, specificity and accuracy for detecting <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content> were 69.7%, 57.1% and 63.2%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The enhancement of <jats:styled-content style=\"fixed-case\">P<jats:sub>1<\/jats:sub>FI<\/jats:styled-content> of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12040","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T12:35:30Z","timestamp":1359376530000},"page":"299-304","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice"],"prefix":"10.1111","volume":"14","author":[{"given":"Kai","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ya","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing 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