{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:39:55Z","timestamp":1769049595477,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Objective<\/jats:title>This study aimed to evaluate the prevalence and significance of serum autoantibodies in alcoholic liver disease (ALD) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>In total, 90 male patients diagnosed with ALD<\/jats:styled-content> or ALD<\/jats:styled-content> overlapping with chronic hepatitis B<\/jats:styled-content> (CHB<\/jats:styled-content>) were included and their medical records were retrospectively reviewed. Clinical data and laboratory findings were collected. Anti\u2010nuclear antibody (ANA<\/jats:styled-content>), anti\u2010mitochondrial antibody (AMA<\/jats:styled-content>) and anti\u2010smooth muscle antibody (SMA<\/jats:styled-content>) were detected by indirect immunofluorescent assay.<\/jats:p><\/jats:sec>Results<\/jats:title>Autoantibodies were found in 69.6% (48\/69) of patients with ALD<\/jats:styled-content> and 66.7% (14\/21) of those with ALD<\/jats:styled-content> overlapping with CHB<\/jats:styled-content>. The prevalence of total ANA<\/jats:styled-content> in ALD<\/jats:styled-content> patients was 63.8% (44\/69). High titers of autoantibodies and multi\u2010autoantibodies were found to be more often associated with cirrhosis than non\u2010cirrhosis. There was a significant difference in the levels of globulin, white blood cell and platelet count (P<\/jats:italic>\u2009<\u20090.05) between patients with positive and negative autoantibodies. However, the values of the other parameters were similar in the two groups. Patients with ALD<\/jats:styled-content> more frequently had positive autoantibodies than those with CHB<\/jats:styled-content> alone (69.6% vs<\/jats:italic> 37.5%, P<\/jats:italic>\u2009<\u20090.01). And 10.4% of ALD<\/jats:styled-content> patients with positive autoantibodies had systemic autoimmune or vascular diseases, which was not found in the CHB<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Autoantibodies are frequently present in patients with ALD<\/jats:styled-content> and correlate to advanced liver disease. A high prevalence of autoantibodies in ALD<\/jats:styled-content> may indicate that alcoholic\u2010associated immune disturbance occurs during the development of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12057","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T12:53:11Z","timestamp":1363870391000},"page":"396-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence and significance of autoantibodies in patients with alcoholic liver disease"],"prefix":"10.1111","volume":"14","author":[{"given":"Min","family":"Lian","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Disease Shanghai 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