{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:39:37Z","timestamp":1765960777221},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aims of this study were to investigate the frequency and factors involved in the terminal ileum intubation of patients with chronic, non\u2010bloody diarrhea and to compare diagnostic yields of colonoscopy and ileocolonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 945 patients undergoing colonoscopy for chronic, non\u2010bloody diarrhea were reviewed. Findings of microscopic colitis, <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>lostridium difficile<\/jats:italic> colitis, celiac disease, inflammatory bowel disease or tropical sprue were considered as definitive causes of diarrhea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 689 patients met the diagnosis of chronic, non\u2010bloody diarrhea, in which 370 (53.7%) underwent ileocolonoscopy. Specific histological diagnosis could explain the patient's symptoms in 107 (15.5%) patients. The diagnostic yield were 15.0% in the colonoscopy\u2010only group, 16.9% in the ileocolonoscopy without biopsy group, and 15.5% in the ileocolonoscopy with biopsy group. Of the 19 patients with an abnormal terminal ileal biopsy, six (31.6%) had an otherwise normal colonic appearance which would have been diagnosed as normal if the ileum had not been reached and biopsied. In those with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease (<jats:italic>n<\/jats:italic>\u2009=\u20097), five had ileocolitis and two had colitis only. A multivariate analysis showed that age of the patients and otherwise normal gross endoscopic results to be the only factors associated with a lower likelihood of ileal intubation by endoscopists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ileal intubation rate was 53.7% in our patients with chronic, non\u2010bloody diarrhea. Diagnostic yield of ileocolonoscopy with biopsy in US patients with chronic, non\u2010bloody diarrhea appeared to be low, if the colon side was normal on endoscopy. But this may provide supportive evidence in patients diagnosed with ileocolonic <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12082","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T15:03:58Z","timestamp":1371567838000},"page":"536-542","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical utility of retrograde terminal ileum intubation in the evaluation of chronic non\u2010bloody diarrhea"],"prefix":"10.1111","volume":"14","author":[{"given":"Rohit","family":"Makkar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.suppl_5.v1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90175-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116483"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70513-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07523.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00201.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00920.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04781.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.056_c.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200009000-00011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(72)73931-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(93)70162-5"},{"key":"e_1_2_5_14_1","first-page":"1441","article-title":"Diagnostic yield of routine ileoscopy","volume":"90","author":"Zwas FR","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(94)70249-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809093915"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03745.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00870.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.5.629"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00503.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1119627"},{"key":"e_1_2_5_22_1","unstructured":"Agence nationale d'accr\u00e9ditation et d'evaluation en sant\u00e9. Endoscopie digestive basse: indications en dehors du d\u00e9pistage en population (2004) \u2013 Argumentaire. (in French). Updated 1 April 2004; Cited: 25 Jun 2013. Available from URL:http:\/\/www.has\u2010sante.fr\/portail\/jcms\/c_272348\/en\/indications\u2010for\u2010lower\u2010gastrointestinal\u2010endoscopy\u2010excluding\u2010population\u2010screening\/"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12082","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:13:16Z","timestamp":1696367596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,2]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/1751-2980.12082"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12082","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,2]]},"assertion":[{"value":"2013-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}