{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:34:45Z","timestamp":1770885285016,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T00:00:00Z","timestamp":1380672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study we aimed to assess the incidence, prevalence and clinical outcomes of patients with autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) in southern <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>srael.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2010finding methods and population\u2010based administrative data were used to evaluate the epidemiology and prognostic factors of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> from 1995 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, the average annual prevalence and incidence of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> in southern <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>srael were 11.0\/100\u2009000 and 0.67\/100\u2009000, respectively. We identified 100 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> cases with a mean age of 47.9 years, including 95 women and five men. Type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> was found in 77 cases, and liver fibrosis and cirrhosis were found in 73.4% and 22.3% of all patients who underwent liver biopsy. In all, 98 patients were treated with a combination of steroids and azathioprine or steroids alone (prednisone and azathioprine in 71, budesonide and azathioprine in 11, prednisone or budesonide alone in six and ten, respectively). Complete remission was recorded in 56 patients, whereas partial response or failure of treatment was noted in 42 patients. In multivariate analysis the independent predictors of remission were the degree of liver fibrosis (mild <jats:italic>vs<\/jats:italic> bridging fibrosis (<jats:styled-content style=\"fixed-case\">F3<\/jats:styled-content>) and cirrhosis [<jats:styled-content style=\"fixed-case\">F4<\/jats:styled-content>]) (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) and level of albumin (<jats:italic>P<\/jats:italic>\u2009=\u20090.031). The estimated 1\u2010year and 10\u2010year survival for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> were 96.5% and 89.7%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>srael is quite similar to that of other <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean Caucasian populations, with a relatively long\u2010term good prognosis, despite a low rate of response to immunosuppressive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12085","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T07:46:54Z","timestamp":1372751214000},"page":"611-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Autoimmune hepatitis in southern <scp>I<\/scp>srael: A 15\u2010year multicenter study"],"prefix":"10.1111","volume":"14","author":[{"given":"Jorge\u2010Shmuel","family":"Delgado","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Barzilai Medical Center Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Vodonos","sequence":"additional","affiliation":[{"name":"Clinical Research Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Malnick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaplan Medical Center Hebrew University  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofra","family":"Kriger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asaf Harofe Medical Center Faculty of Health Sciences Tel Aviv University  Rehovot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renana","family":"Wilkof\u2010Segev","sequence":"additional","affiliation":[{"name":"Clinical Research Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Pathology Clalit Medical Services  Ashkelon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Novack","sequence":"additional","affiliation":[{"name":"Clinical Research Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Soroka University Medical Center and Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Menachem","sequence":"additional","affiliation":[{"name":"Liver Unit Clalit Medical Services  Ashkelon Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Melzer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kaplan Medical Center Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Fich","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Soroka University Medical Center and Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 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