{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T18:22:56Z","timestamp":1743531776502},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T00:00:00Z","timestamp":1380672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Objectives<\/jats:title>We aimed to determine the prevalence of chronic and past hepatitis B virus (HBV) infection in Chinese patients with inflammatory bowel disease (IBD), and to determine the risk factors associated with having received no vaccination for HBV and abnormal liver function among our patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>The prevalence of chronic or past infection with HBV<\/jats:styled-content> infection and effective HBV<\/jats:styled-content> vaccination were determined in patients with IBD who attended the IBD Clinic of the Queen Mary Hospital in Hong Kong, China. Risk factors associated with the absence of HBV vaccination and abnormal liver function were identified.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 267 C<\/jats:styled-content>hinese IBD<\/jats:styled-content> patients (166 ulcerative colitis and 101 C<\/jats:styled-content>rohn's disease) were enrolled. The mean follow\u2010up period was 10.5 years. Chronic and past HBV<\/jats:styled-content> infection was detected in 6.7% and 28.5% patients, respectively. Altogether 102 patients lacked effective HBV vaccination. Multivariate analysis found that elder age at diagnosis of IBD (OR<\/jats:styled-content> 1.02, 95% CI<\/jats:styled-content> 1.00\u20130.94) and the absence of using thiopurine (OR<\/jats:styled-content> 0.53, 95% CI<\/jats:styled-content> 0.29\u20130.94) were associated with the presence of anti\u2010HBs. A<\/jats:styled-content>bnormal liver function was detected in 27 (10.1%) patients. The use of anti\u2010tumor necrosis factor agents (OR<\/jats:styled-content> 4.6, 95% CI<\/jats:styled-content> 1.3\u221216.0), previous bowel resection (OR<\/jats:styled-content> 3.7, 95% CI<\/jats:styled-content> 1.5\u20139.2) and male gender (OR<\/jats:styled-content> 4.4, 95% CI<\/jats:styled-content> 1.4\u221213.7) were significant risk factors for abnormal liver function.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The use of thiopurine and younger age at diagnosis were associated with no vaccination against HBV<\/jats:styled-content> in Chinese IBD<\/jats:styled-content> patients. Chronic or past HBV<\/jats:styled-content> infection was, however, not associated with abnormal liver function in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12089","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T11:14:36Z","timestamp":1374232476000},"page":"596-603","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors for hepatitis B<\/scp> vaccination and abnormal liver function in C<\/scp>hinese patients with inflammatory bowel disease: A single center experience"],"prefix":"10.1111","volume":"14","author":[{"given":"Wai K","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Medicine University of Hong Kong Queen Mary Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin SH","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Hong Kong 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