{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:27:54Z","timestamp":1790544474505,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T00:00:00Z","timestamp":1383609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Objective<\/jats:title>To analyze autonomic functioning which presented as the high frequency (HF<\/jats:styled-content>) component of heart rate variability, a measurement of vagal tone, and the ratio of low frequency (LF<\/jats:styled-content>) to HF<\/jats:styled-content> (LF\u2009:\u2009HF), an indicator of sympathovagal balance in irritable bowel syndrome (IBS)<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We identified relevant studies by performing a literature search of MEDLINE<\/jats:styled-content>, EMBASE<\/jats:styled-content> and the ISI<\/jats:styled-content> Web of Knowledge to 31 M<\/jats:styled-content>arch 2013. Pooled effect sizes with 95% confidence interval (CI<\/jats:styled-content>) were calculated using a random effects model. Between\u2010study heterogeneity was assessed using the Q<\/jats:styled-content> test and I<\/jats:styled-content><\/jats:italic>2<\/jats:sup> statistic.<\/jats:p><\/jats:sec>Results<\/jats:title>In all, 11 articles including 392 IBS<\/jats:styled-content> patients and 263 controls met the inclusion criteria of the analysis. IBS<\/jats:styled-content> patients had lower HF<\/jats:styled-content> band power (H<\/jats:styled-content>edges's g\u2009=\u2009\u22120.38, 95% CI<\/jats:styled-content> \u22120.68 to \u22120.09) than the controls (I<\/jats:styled-content><\/jats:italic>2<\/jats:sup>\u2009=\u200963.6%, P<\/jats:italic>\u2009=\u20090.003). Moreover, IBS<\/jats:styled-content> patients showed a higher LF<\/jats:styled-content>\u2009:\u2009HF<\/jats:styled-content> (H<\/jats:styled-content>edges's g\u2009=\u20090.43, 95% CI<\/jats:styled-content> 0.13\u20130.74), with no significant heterogeneity. A subgroup analysis of the HF<\/jats:styled-content> index according to the recording time yielded different results for the IBS<\/jats:styled-content> patients and controls. Additionally, constipation\u2010predominant IBS<\/jats:styled-content> (IBS<\/jats:styled-content>\u2010C<\/jats:styled-content>) patients had decreased HF<\/jats:styled-content> band power, whereas no significant difference was found in LF<\/jats:styled-content>\u2009:\u2009HF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Impaired parasympathetic functioning and abnormal sympathovagal balance may be involved in the pathogenesis of IBS<\/jats:styled-content>. Vagal dysfunction is more obvious in the IBS<\/jats:styled-content>\u2010C<\/jats:styled-content> subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12092","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T15:20:16Z","timestamp":1375975216000},"page":"638-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Autonomic functioning in irritable bowel syndrome measured by heart rate variability: A meta\u2010analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Ren Ji Hospital, School of Medicine Shanghai Jiaotong University, Shanghai Institute of Digestive Disease Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er Man","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ren Ji Hospital, School of 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