{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:39:13Z","timestamp":1764783553049},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Objective<\/jats:title>This study was aimed to determine the prevalence of celiac disease (CD) in irritable bowel syndrome (IBS) and its subtypes in a group of Iranian patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>From M<\/jats:styled-content>arch 2007 to J<\/jats:styled-content>une 2009, 465 consecutive patients who were referred to the gastroenterology clinic of Jundishapur University of Medical Sciences and fulfilled the Rome III<\/jats:styled-content> criteria for IBS<\/jats:styled-content> were included. Immunoglobulin A (IgA) anti\u2010tissue transglutaminase (IgA\u2010tTG) and anti\u2010gliadin antibody (AGA<\/jats:styled-content>) levels were measured. CD<\/jats:styled-content> was confirmed by gastroduodenoscopy and biopsy in patients with abnormal antibodies.<\/jats:p><\/jats:sec>Results<\/jats:title>Five patients had only elevated IgA\u2010tTG, 26 with only elevated AGA<\/jats:styled-content>, and in 16 patients abnormal results for both antibodies were reported. Duodenal biopsies from these 47 patients confirmed CD<\/jats:styled-content> in 13 (2.8%, 95% CI<\/jats:styled-content> 1.6\u20134.0%) according to the Marsh criteria. Two CD<\/jats:styled-content> patients had normal IgA\u2010tTG concentrations while only one patient with normal AGA<\/jats:styled-content> was proven to have CD<\/jats:styled-content>. CD<\/jats:styled-content> was most prevalent in unsubtyped IBS<\/jats:styled-content> (4.9%, 95% CI 1.1\u20138.7%), followed by mixed IBS<\/jats:styled-content> (4.7%, 95% CI 0.3\u20139.1%). In multiple comparison, CD<\/jats:styled-content> was less common in diarrhea\u2010predominant IBS than in unsubtyped IBS<\/jats:styled-content>, although this did not reach statistical significance (1.0% vs<\/jats:italic> 4.9%, P<\/jats:italic>\u2009=\u20090.057).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CD in unsubtyped IBS had a growing trend to be more common than in diarrhea\u2010predominant IBS. Evaluation of IBS<\/jats:styled-content> patients for CD<\/jats:styled-content> is advisable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12102","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:45:41Z","timestamp":1381527941000},"page":"12-17","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of celiac disease in I<\/scp>ranian patients with irritable bowel syndrome: A cross\u2010sectional study"],"prefix":"10.1111","volume":"15","author":[{"given":"Ali Akbar","family":"Shayesteh","sequence":"first","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive System School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eskandar","family":"Hajiani","sequence":"additional","affiliation":[{"name":"Research Institute for Infectious Diseases of Digestive 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