{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:11:26Z","timestamp":1696482686952},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Objective<\/jats:title>We aimed to investigate the association between a family history (FH) of colorectal cancer (CRC) and cancer recurrence and survival in patients with stage III CRC.<\/jats:p><\/jats:sec>Methods<\/jats:title>From A<\/jats:styled-content>pril 2001 to D<\/jats:styled-content>ecember 2007, 1102 patients with stage III CRC<\/jats:styled-content> were enrolled and their data including FH, clinicopathological characteristics of the tumor were retrospectively analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 971 patients that were finally enrolled, 63 (6.5%) reported CRC<\/jats:styled-content> in at least one first\u2010degree relative. Death occurred in 12.7% of the CRC<\/jats:styled-content> patients with an FH and 21.8% in those without an FH. A multivariate analysis showed that patients with an FH of CRC, compared with those without FH<\/jats:styled-content>, had an adjusted hazard ratios (HR<\/jats:styled-content>) of 0.674 (P<\/jats:italic>\u2009=\u20090.281) for overall survival (OS<\/jats:styled-content>) and 0.672 (P<\/jats:italic>\u2009=\u20090.220) for disease\u2010free survival (DFS<\/jats:styled-content>). However, the location of tumor, preoperative carcinoembryonic antigen (CEA<\/jats:styled-content>) level, tumor invasion (T<\/jats:styled-content>) stage and lymph node (N<\/jats:styled-content>) metastasis significantly affected OS<\/jats:styled-content> and DFS<\/jats:styled-content>. Furthermore, whereas the FH<\/jats:styled-content> of CRC<\/jats:styled-content> patients was associated with a favorable prognosis in stage III<\/jats:styled-content> colon cancer (HR 0.224, P<\/jats:italic>\u2009=\u20090.040) but not in rectal cancer (HR 1.225, P<\/jats:italic> = 0.640).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>I<\/jats:styled-content>n patients with stage III CRC<\/jats:styled-content>, tumor location (especially in the rectum), a high preoperative CEA level and advanced T<\/jats:styled-content> and N<\/jats:styled-content> stages indicate a poor prognosis. However, in stage III<\/jats:styled-content> colon cancer FH<\/jats:styled-content> is associated with improved survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12120","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T08:02:56Z","timestamp":1386230576000},"page":"108-115","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of family history on survival in patients with colon and rectal cancer"],"prefix":"10.1111","volume":"15","author":[{"given":"Seong Dae","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Chang","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Su","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Won","family":"Hong","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Kyung","family":"Sohn","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Won","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yeon","family":"Baek","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jin","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Center for Colorectal Cancer Research Institute and Hospital National Cancer Center Goyang\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"1975 National Cancer Institute Bethesda MD S Altekruse C Kosary M Krapcho SEER Cancer Statistics Review"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.8.1113"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412223312501"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04677.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.21.1618"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.11.059"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001133420201"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608876"},{"key":"e_1_2_6_11_1","first-page":"343","article-title":"Correlation between family history of colorectal cancer and pathological and clinical features of the disease","volume":"18","author":"Aste H","year":"1994","journal-title":"Cancer Detect Prev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891101)64:9<1971::AID-CNCR2820640935>3.0.CO;2-L"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/oxfordjournals.jjco.a039659","article-title":"Clinical and pathological analyses of patients with a family history of colorectal cancer","volume":"23","author":"Registry Committee, Japanese Research Society for Cancer of the Colon and Rectum","year":"1993","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/24.5.888"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.21.2515"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0774-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0587"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23294"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90549-H"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9286-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-008-9190-z"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31817fc2a0"},{"key":"e_1_2_6_23_1","first-page":"209","article-title":"Comparison of survival between patients with hereditary non polyposis colorectal cancer (HNPCC) and sporadic colorectal cancer","volume":"10","author":"Haghighi MM","year":"2009","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-39"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_6_26_1","first-page":"787","article-title":"Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first\u2010degree member affected by colon cancer","volume":"63","author":"Ricciardiello L","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_27_1","first-page":"917","article-title":"Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level","volume":"10","author":"Samowitz WS","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00845.x"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12120","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:11:20Z","timestamp":1696396280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,14]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/1751-2980.12120"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12120","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,14]]},"assertion":[{"value":"2014-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}