{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:31:57Z","timestamp":1769110317976,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,16]],"date-time":"2014-03-16T00:00:00Z","timestamp":1394928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Objective<\/jats:title>Our aim was to identify risk factors for acute gastrointestinal (GI) bleeding in patients with myocardial infarction (MI) who were prescribed clopidogrel following hospital discharge.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were collected retrospectively from patients treated in V<\/jats:styled-content>eteran A<\/jats:styled-content>ffairs hospitals in Ohio, USA, from 2001 to 2008 with a primary diagnosis of MI (I<\/jats:styled-content>nternational C<\/jats:styled-content>lassification of D<\/jats:styled-content>iseases, 9th R<\/jats:styled-content>evision) and a prescription for clopidogrel filled within 48 h of discharge. Primary outcome was acute GI<\/jats:styled-content> bleeding after discharge.<\/jats:p><\/jats:sec>Results<\/jats:title>Acute GI<\/jats:styled-content> bleeding occurred in 107 of 3218 patients. Bleeding occurred in those who were elder (66.2 vs<\/jats:italic> 62.4 years, P<\/jats:italic>\u2009=\u20090.0002), had lower glomerular filtration rate (74 vs<\/jats:italic> 81\u2009mL\/min, P<\/jats:italic>\u2009=\u20090.024), had filled prescription for warfarin (15.9% vs<\/jats:italic> 6.9%, P<\/jats:italic>\u2009=\u20090.0004), diagnosed as atrial fibrillation (20.6% vs<\/jats:italic> 11.1%, P<\/jats:italic>\u2009=\u20090.003), chronic liver (5.6% vs<\/jats:italic> 2.2%, P<\/jats:italic>\u2009=\u20090.018) or kidney disease (29.0% vs 19.4%, P<\/jats:italic>\u2009=\u20090.016). A risk model and GI<\/jats:styled-content> bleed risk score were developed and showed that patients with age >65 years, use of warfarin, the presence of chronic liver or kidney disease were at increased risk for GI bleeding.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Veterans patients of advanced age, using warfarin and with chronic liver and kidney disease may be at increased risk of GI<\/jats:styled-content> bleeding when prescribed clopidogrel following MI. A scoring system may help to identify patients at high risk for GI<\/jats:styled-content> bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12123","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T07:22:37Z","timestamp":1388042557000},"page":"195-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for acute gastrointestinal bleeding following myocardial infarction in veteran patients who are prescribed clopidogrel"],"prefix":"10.1111","volume":"15","author":[{"given":"Justin R","family":"Cuschieri","sequence":"first","affiliation":[{"name":"Louis Stokes VA Medical Center Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Drawz","sequence":"additional","affiliation":[{"name":"Louis Stokes VA Medical Center Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yngve","family":"Falck\u2010Ytter","sequence":"additional","affiliation":[{"name":"Louis Stokes VA Medical Center Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C K","family":"Wong","sequence":"additional","affiliation":[{"name":"Louis Stokes VA Medical Center Cleveland Ohio USA"},{"name":"Division of Gastroenterology and Liver Disease University Hospitals Case Medical Center Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.4.509"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6983.827"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010746"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901301"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-006-9005-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01715.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.038"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61751-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.07.039"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.06.011"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160457"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820f2f3e"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.015"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp256"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.019"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.928721"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.09.011"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.261"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.082001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.064"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-12-0808"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008315310"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0299-0"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007964"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0140-6736(09)61525-7","article-title":"Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton\u2010pump inhibitor: an analysis of two randomised trials","volume":"37426","author":"O'Donoghue ML","year":"2009","journal-title":"Lancet"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.445"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.002"}],"container-title":["Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1751-2980.12123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-2980.12123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:20:54Z","timestamp":1696382454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1751-2980.12123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,16]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/1751-2980.12123"],"URL":"https:\/\/doi.org\/10.1111\/1751-2980.12123","archive":["Portico"],"relation":{},"ISSN":["1751-2972","1751-2980"],"issn-type":[{"value":"1751-2972","type":"print"},{"value":"1751-2980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,16]]},"assertion":[{"value":"2014-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}