{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:25:07Z","timestamp":1781069107838,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,16]],"date-time":"2014-03-16T00:00:00Z","timestamp":1394928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Objective<\/jats:title>The aim of this study was to investigate the role of insulin\u2010like growth factor binding protein\u2010related protein 1 (IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1) in the development of hepatic fibrogenesis in experimental disease models and human liver samples.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cellular distribution patterns of IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1 were assessed by immunohistochemistry in fibrotic and cirrhotic human liver specimens. Gene silencing of IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1<\/jats:italic> was performed on cultured hepatic stellate cells (HSCs<\/jats:styled-content>) by small interfering RNA<\/jats:styled-content> (siRNA<\/jats:styled-content>), and the silencing effect was determined by quantitative real\u2010time polymerase chain reaction (PCR<\/jats:styled-content>) and Western blot. We also determined the effects of siRNA<\/jats:styled-content>\u2010mediated gene silencing of IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1<\/jats:italic> on the production of extracellular matrix (ECM<\/jats:styled-content>) components by W<\/jats:styled-content>estern blot. The expression of ECM<\/jats:styled-content> components and transforming growth factor (TGF<\/jats:styled-content>)\u2010\u03b21 was studied by immunohistochemistry and Western blot in C57BL<\/jats:styled-content>\/6 wild\u2010type mice treated with recombinant IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1 (rIGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1).<\/jats:p><\/jats:sec>Results<\/jats:title>Expression of IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1 was significantly elevated in fibrotic and cirrhotic human liver specimens, and this increase was positively correlated with the number of collagen fibers observed. siRNA<\/jats:styled-content>\u2010mediated gene silencing of IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1<\/jats:italic> resulted in significantly decreased levels of collagen I<\/jats:styled-content> and fibronectin in HSCs<\/jats:styled-content>. Moreover, IGFBP<\/jats:styled-content>\u2010rP1 overexpression significantly increased the production of collagen, fibronectin and TGF\u2010\u03b21<\/jats:styled-content> in rIGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1\u2010treated mice.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IGFBP<\/jats:styled-content>\u2010rP<\/jats:styled-content>1 contributes to the development of liver fibrosis and may be a novel molecule involved in the progression of hepatic fibrogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12126","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T03:54:59Z","timestamp":1388030099000},"page":"202-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Insulin\u2010like growth factor binding protein\u2010related protein 1 contributes to hepatic fibrogenesis"],"prefix":"10.1111","volume":"15","author":[{"given":"Xiao Hong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Hospital of Shanxi Medical University Taiyuan Shanxi Province China"},{"name":"Experimental Center of Science and Research The First Hospital of Shanxi Medical University Taiyuan Shanxi Province China"},{"name":"Key Laboratory of Cell Physiology, Provincial Department of the Ministry of Education Shanxi Medical University Taiyuan Shanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Hospital of Shanxi Medical University Taiyuan Shanxi Province China"},{"name":"Experimental Center of Science and Research The First Hospital of Shanxi Medical University Taiyuan Shanxi Province China"},{"name":"Key Laboratory of Cell Physiology, Provincial Department of the Ministry of Education Shanxi Medical University Taiyuan 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