{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:19:47Z","timestamp":1791559187290,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine the effect of antithrombotics on in\u2010hospital mortality and morbidity in patients with peptic ulcer disease\u2010related upper gastrointestinal bleeding (PUD\u2010related UGIB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort was retrospectively selected from a tertiary center database of patients with PUD\u2010related UGIB, defined as bleeding due to gastric or duodenal ulcers, or erosive duodenitis, gastritis or esophagitis. Outcomes were compared among patient groups based on their antithrombotic medications before admission. Patients on no antithrombotics served as controls. The composite adverse outcomes, in\u2010hospital mortality, rebleeding and\/or need for surgery were measured. Severe bleeding and in\u2010hospital complications were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 398 patients with PUD\u2010related UGIB, 44.5% were on aspirin or anticoagulants only. The composite adverse outcome was most common in patients taking anticoagulants only (40.5%), intermediate in controls (23.1%) and least in those taking aspirin only (12.1%). On multivariate analysis, patients taking aspirin alone had a significantly lower risk of adverse outcome events (odds ratio [OR] 0.4, 95% CI 0.2\u20130.8) and a shorter length of hospital stay (regression coefficient\u2009=\u2009\u22123.4, 95% CI [\u22126.6, \u22120.6]). In contrast, taking anticoagulants was associated with a greater risk of adverse outcome events (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u20092.3, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20135.3), severe bleeding (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u20092.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20135.8) and in\u2010hospital complications (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u20092.9, 95% CI 1.3\u20136.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with PUB\u2010related UGIB while taking aspirin had fewer adverse outcomes compared with those taking anticoagulants. Aspirin may have beneficial effects in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12140","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T05:30:38Z","timestamp":1393997438000},"page":"283-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Opposing effects of aspirin and anticoagulants on morbidity and mortality in patients with upper gastrointestinal bleeding"],"prefix":"10.1111","volume":"15","author":[{"given":"Hussein","family":"Abu Daya","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Division of Gastroenterology and Hepatology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Eloubeidi","sequence":"additional","affiliation":[{"name":"Division of 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