{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:08:02Z","timestamp":1762430882826},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aims of this study were to clarify the kinetics of intestinal barrier function impairment in sodium taurocholate\u2010induced severe acute pancreatitis (<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>) models and to explore an appropriate concentration of sodium taurocholate and a suitable time point for further study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 104 rats were randomly divided into four groups: the normal control group (<jats:italic>n<\/jats:italic>\u2009=\u20098) receiving no treatment, the sham\u2010operation group (<jats:italic>n<\/jats:italic>\u2009=\u200932), the 2.5% and 5% sodium taurocholate\u2010treated SAP groups (<jats:italic>n<\/jats:italic>\u2009=\u200932 for each group) which were induced via a retrograde injection of 2.5% or 5% sodium taurocholate into the pancreatic duct. Histological examination, serum D\u2010lactate and endotoxin levels and the incidence of bacteria translocation were recorded to assess the intestinal mucosal injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pancreatitis models were successfully established in both the 2.5% and 5% sodium taurocholate\u2010treated groups. The dosage of sodium taurocholate used to induce pancreatitis was positively correlated with the degree of intestinal mucosal injury. The most severe damage to intestinal barrier was observed 24\u2009h after surgery in the 2.5% sodium taurocholate\u2010treated group and 48\u2009h after surgery in the 5% sodium taurocholate\u2010treated group, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the success rate of the model, the mortality and the impairment of intestinal barrier function, we conclude that 24\u2009h after a retrograde injection of 2.5% sodium taurocholate may be the most appropriate time point to study intestinal barrier injury in <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content> rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1751-2980.12148","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T05:30:47Z","timestamp":1396416647000},"page":"386-393","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Time course of intestinal barrier 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