{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:09:19Z","timestamp":1777342159579,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Digest Diseases"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p><jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>lostridium difficile<\/jats:italic> infection (<jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>) is an increasingly common and severe international health problem. Customary treatment of this infection, usually with antibiotics, is often ineffective and its recurrence is common. In recent years the treatment of recurrent or refractory <jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content> by the transfer of stool from an uninfected person, so called fecal \u201cmicrobiota transplantation\u201d has become recognized as effective and generally safe. The effectiveness of this novel treatment is incompletely defined but is likely to be due to its correction of the intestinal dysbiosis that characterizes the disease. Practical methods for the administration of the transplantation have been described. This review summarizes the current reported experiences with fecal microbiota transplantation in the treatment for <jats:styled-content style=\"fixed-case\">CDI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1751-2980.12160","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T03:01:10Z","timestamp":1400036470000},"page":"405-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fecal microbiota transplantation in treating <i><scp>C<\/scp>lostridium difficile<\/i> infection"],"prefix":"10.1111","volume":"15","author":[{"given":"William R","family":"Brown","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp011603"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Treatment of relapsing Clostridium difficile infection using fecal microbiota transplantation","volume":"7","author":"Pathak R","year":"2013","journal-title":"Clin Exp Gastroenterol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.037"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/501553"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.251"},{"key":"e_1_2_7_7_1","first-page":"854","article-title":"Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis","volume":"44","author":"Eiseman B","year":"1958","journal-title":"Surgery"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90753-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.450"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir632"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002995"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081330"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.12.032"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2088-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0307-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12320"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.60"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12577"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.02.017"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000355955","article-title":"Analysis of the intestinal microbiome of a recovered Clostridium difficile patient after fecal transplantation","volume":"88","author":"Broecker F","year":"2013","journal-title":"Digestion"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000046"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2013.e13"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit950"},{"key":"e_1_2_7_24_1","unstructured":"FDA. Guidance for industry: enforcement policy regarding investigational new drug requirements for use of fecal microbiota for transplantation to treatClostridium difficileinfection not responsive to standard therapies.2013July 18. Cited 20 May 2014. 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